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Faculty DataBase - FDB5

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Linda Demer, M.D., Ph.D.

   
Professor, Medicine, Physiology, Bioengineering
Executive Director, UCLA Specialty Training and Advanced Research (STAR) Program
Executive Vice Chair, Medicine

Education:
Degrees:
M.D., Johns Hopkins University School of Medicine, 1983
Ph.D., The Johns Hopkins University School of Medicine, 1983
B.S., University of Arizona, 1977

Certifications:
Certifications:
1989 American Board of Internal Medicine
1986 American Board of Internal Medicine

Honors and Awards:
American Heart Association, Jeffrey M. Hoeg Award for Basic Science and Clinical Research
Stein/Oppenheimer Endowment, Franklin D. Murphy, M.D., Prize for Research
Royal College of Physicians of Edinburgh, Davidson Memorial Endowed Lectureship
UCLA Chancellor, Academic Border Crossing Award
Stein/Oppenheimer Endowment, Stein/Oppenheimer Award for Biomedical Research
Temple University School of Medicine, Stewart-Niewiarowski Award for Vascular Biology Research

Contact Information:
Work Email Address: ldemer@mednet.ucla.edu
Mailing Address: David Geffen School of Medicine at UCLA
Medicine, Physiology, and Bioengineering
A2-237 CHS
Los Angeles, CA 90095
UNITED STATES
Work Address: Office
UCLA Department of Medicine
Box 951679, CHS 17-052
Los Angeles, CA 90095
UNITED STATES
Home Page: http://www.uclahealth.org/LindaDemer
ARR Papers: http://www.cnsi.ucla.edu/arr/personnel-papers?personnel_id=8724
Home Page: http://www.cardiology.med.ucla.edu/faculty/demercv.htm
Office Phone Number: (310) 206-2677 Office
Work Phone Number: (310) 825-8811 Work

Selected Publications:

Demer Linda L, Tintut Yin, Reply: Evolutionary approach sheds light on the significance of vascular calcification, Trends in cardiovascular medicine, 2017, 27 (1), 72.
Tintut Yin, Demer Linda L, COMP-lex Mechanics: Matricrine Signaling, Circulation research, 2016, 119 (2), 184-6.
Hsu Jeffrey J, Lim Jina, Tintut Yin, Demer Linda L, Cell-matrix mechanics and pattern formation in inflammatory cardiovascular calcification, Heart (British Cardiac Society), 2016, 102 (21), 1710-1715.
Lim Jina, Ehsanipour Arshia, Hsu Jeffrey J, Lu Jinxiu, Pedego Taylor, Wu Alexander, Walthers Chris M, Demer Linda L, Seidlits Stephanie K, Tintut Yin, Inflammation Drives Retraction, Stiffening, and Nodule Formation via Cytoskeletal Machinery in a Three-Dimensional Culture Model of Aortic Stenosis, The American journal of pathology, 2016, 186 (9), 2378-89.
Wong Mitchell D, Guerrero Lourdes, Sallam Tamer, Frank Joy S, Fogelman Alan M, Demer Linda L, Outcomes of a Novel Training Program for Physician-Scientists: Integrating Graduate Degree Training With Specialty Fellowship, Journal of graduate medical education, 2016, 8 (1), 85-90.
Packard René R Sevag, Zhang XiaoXiao, Luo Yuan, Ma Teng, Jen Nelson, Ma Jianguo, Demer Linda L, Zhou Qifa, Sayre James W, Li Rongsong, Tai Yu-Chong, Hsiai Tzung K, Two-Point Stretchable Electrode Array for Endoluminal Electrochemical Impedance Spectroscopy Measurements of Lipid-Laden Atherosclerotic Plaques, Annals of biomedical engineering, 2016, 44 (9), 2695-706.
Demer Linda L, Boström Kristina I, Conflicting forces of warfarin and matrix gla protein in the artery wall, Arteriosclerosis, thrombosis, and vascular biology, 2015, 35 (1), 9-10.
Tintut Yin, Demer Linda L, Exosomes: nanosized cellular messages, Circulation research, 2015, 116 (8), 1281-3.
Li Xin, Lim Jina, Lu Jinxiu, Pedego Taylor M, Demer Linda, Tintut Yin, Protective Role of Smad6 in Inflammation-Induced Valvular Cell Calcification, Journal of cellular biochemistry, 2015, 116 (10), 2354-64.
Demer Linda L, Tintut Yin, The leading edge of vascular calcification, Trends in cardiovascular medicine, 2015, 25 (4), 275-7.
Yutzey Katherine E, Demer Linda L, Body Simon C, Huggins Gordon S, Towler Dwight A, Giachelli Cecilia M, Hofmann-Bowman Marion A, Mortlock Douglas P, Rogers Melissa B, Sadeghi Mehran M, Aikawa Elena, Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease, Arteriosclerosis, thrombosis, and vascular biology, 2014, 34 (11), 2387-93.
van Venrooij N A, Pereira RC, Tintut Y, Fishbein MC, Tumber N, Demer LL, Salusky IB, Wesseling-Perry K, FGF23 protein expression in coronary arteries is associated with impaired kidney function, Nephrol Dial Transpl, 2014, 34 (4), in press.
Demer Linda L, Tintut Yin, Inflammatory, metabolic, and genetic mechanisms of vascular calcification, Arteriosclerosis, thrombosis, and vascular biology, 2014, 34 (4), 715-23.
Tintut Yin, Demer Linda L, Effects of bioactive lipids and lipoproteins on bone, Trends in endocrinology and metabolism: TEM, 2013.
Heistad Donald D, Shanahan Catherine, Demer Linda L, Introduction to the Compendium on calcific aortic valve disease, Circulation research, 2013, 113 (2), 176-8.
Li Xin, Garcia Jamie, Lu Jinxiu, Iriana Sidney, Kalajzic Ivo, Rowe David, Demer Linda, Tintut Yin, Mechanism of hyperlipidemia-induced parathyroid hormone (PTH) resistance: A role of PTH receptor and reactive oxygen species in preosteoblasts, Journal of cellular biochemistry, 2013.
Lu Jinxiu, Cheng Henry, Atti Elisa, Shih Diana M, Demer Linda L, Tintut Yin, Role of paraoxonase-1 in bone anabolic effects of parathyroid hormone in hyperlipidemic mice, Biochemical and biophysical research communications, 2013, 431 (1), 19-24.
Pirih Flavia, Lu Jinxiu, Ye Fei, Bezouglaia Olga, Atti Elisa, Ascenzi Maria-Grazia, Tetradis Sotirios, Demer Linda, Aghaloo Tara, Tintut Yin, Adverse effects of hyperlipidemia on bone regeneration and strength, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2012, 27 (2), 309-18.
Chen Ting-Hsuan, Zhu Xiaolu, Pan Leiting, Zeng Xingjuan, Garfinkel Alan, Tintut Yin, Demer Linda L, Zhao Xin, Ho Chih-Ming, Directing tissue morphogenesis via self-assembly of vascular mesenchymal cells, Biomaterials, 2012, 33 (35), 9019-26.
Morony S, Sage AP, Corbin T, Lu J, Tintut Y, Demer LL., Enhanced mineralization potential of vascular cells from SM22alpha-RANKL(tg) mice, Am J Physiol Heart Circ Physiol, 2012, 91 (6), 379-86.
Chen Ting-Hsuan, Hsu Jeffrey J, Zhao Xin, Guo Chunyan, Wong Margaret N, Huang Yi, Li Zongwei, Garfinkel Alan, Ho Chih-Ming, Tintut Yin, Demer Linda L, Left-right symmetry breaking in tissue morphogenesis via cytoskeletal mechanics, Circulation research, 2012, 110 (4), 551-9.
Chen Ting-Hsuan, Guo Chunyan, Zhao Xin, Yao Yucheng, Boström Kristina I, Wong Margaret N, Tintut Yin, Demer Linda L, Ho Chih-Ming, Garfinkel Alan, Patterns of periodic holes created by increased cell motility, Interface focus, 2012, 2 (4), 457-64.
Wong Margaret N, Nguyen Timothy P, Chen Ting-Hsuan, Hsu Jeffrey J, Zeng Xingjuan, Saw Aman, Demer Eric M, Zhao Xin, Tintut Yin, Demer Linda L, Preferred mitotic orientation in pattern formation by vascular mesenchymal cells, American journal of physiology. Heart and circulatory physiology, 2012, 303 (12), H1411-7.
Rajamannan Nalini M, Evans Frank J, Aikawa Elena, Grande-Allen K Jane, Demer Linda L, Heistad Donald D, Simmons Craig A, Masters Kristyn S, Mathieu Patrick, O'Brien Kevin D, Schoen Frederick J, Towler Dwight A, Yoganathan Ajit P, Otto Catherine M, Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update, Circulation, 2011, 124 (16), 1783-91.
Sage Andrew P, Lu Jinxiu, Atti Elisa, Tetradis Sotirios, Ascenzi Maria-Grazia, Adams Douglas J, Demer Linda L, Tintut Yin, Hyperlipidemia induces resistance to PTH bone anabolism in mice via oxidized lipids, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011, 26 (6), 1197-206.
Sage Andrew P, Lu Jinxiu, Tintut Yin, Demer Linda L, Hyperphosphatemia-induced nanocrystals upregulate the expression of bone morphogenetic protein-2 and osteopontin genes in mouse smooth muscle cells in vitro, Kidney international, 2011, 79 (4), 414-22.
Ting Tabitha C, Miyazaki-Anzai Shinobu, Masuda Masashi, Levi Moshe, Demer Linda L, Tintut Yin, Miyazaki Makoto, Increased lipogenesis and stearate accelerate vascular calcification in calcifying vascular cells, The Journal of biological chemistry, 2011, 286 (27), 23938-49.
Geng Yifan, Hsu Jeffrey J, Lu Jinxiu, Ting Tabitha C, Miyazaki Makoto, Demer Linda L, Tintut Yin, Role of cellular cholesterol metabolism in vascular cell calcification, The Journal of biological chemistry, 2011, 286 (38), 33701-6.
Byon Chang Hyun, Sun Yong, Chen Jianfeng, Yuan Kaiyu, Mao Xia, Heath Jack M, Anderson Peter G, Tintut Yin, Demer Linda L, Wang Deli, Chen Yabing, Runx2-upregulated receptor activator of nuclear factor κB ligand in calcifying smooth muscle cells promotes migration and osteoclastic differentiation of macrophages, Arteriosclerosis, thrombosis, and vascular biology, 2011, 31 (6), 1387-96.
Demer Linda, Tintut Yin, The roles of lipid oxidation products and receptor activator of nuclear factor-κB signaling in atherosclerotic calcification, Circulation research, 2011, 108 (12), 1482-93.
Towler Dwight A, Demer Linda L, Thematic series on the pathobiology of vascular calcification: an introduction, Circulation research, 2011, 108 (11), 1378-80.
Sage Andrew P, Lu Jinxiu, Atti Elisa, Tetradis Sotirios, Ascenzi Maria-Grazia, Adams Douglas J, Demer Linda L, Tintut Yin, Hyperlipidemia induces resistance to PTH bone anabolism in mice via oxidized lipids, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2010, 79 (4).
Tseng Wendy, Graham Lucia S, Geng Yifan, Reddy Aneela, Lu Jinxiu, Effros Rita B, Demer Linda, Tintut Yin, PKA-induced receptor activator of NF-kappaB ligand (RANKL) expression in vascular cells mediates osteoclastogenesis but not matrix calcification, The Journal of biological chemistry, 2010, 285 (39), 29925-31.
Tseng Wendy, Lu Jinxiu, Bishop Gail A, Watson Andrew D, Sage Andrew P, Demer Linda, Tintut Yin, Regulation of interleukin-6 expression in osteoblasts by oxidized phospholipids, Journal of lipid research, 2010, 51 (5), 1010-6.
Sage Andrew P, Tintut Yin, Demer Linda L, Regulatory mechanisms in vascular calcification, Nature reviews. Cardiology, 2010, 7 (9), 528-36.
Demer Linda, Tintut Yin, The bone-vascular axis in chronic kidney disease, Current opinion in nephrology and hypertension, 2010, 19 (4), 349-53.
Demer Linda L, Tintut Yin, Mechanisms linking osteoporosis with cardiovascular calcification, Current osteoporosis reports, 2009, 7 (2), 42-6.
Graham Lucia S, Parhami Farhad, Tintut Yin, Kitchen Christina M R, Demer Linda L, Effros Rita B, Oxidized lipids enhance RANKL production by T lymphocytes: implications for lipid-induced bone loss, Clinical immunology (Orlando, Fla.), 2009, 133 (2), 265-75.
Sage Andrew, Tintut Yin, Garfinkel Alan, Demer Linda, Systems biology of vascular calcification, Trends in cardiovascular medicine, 2009, 19 (4), 118-23.
Hsu Jeffrey J, Lu Jinxiu, Huang Michael S, Geng Yifan, Sage Andrew P, Bradley Michelle N, Tontonoz Peter, Demer Linda L, Tintut Yin, T0901317, an LXR agonist, augments PKA-induced vascular cell calcification, FEBS letters, 2009, 583 (8), 1344-8.
Hsu Jeffrey J, Tintut Yin, Demer Linda L, Murine models of atherosclerotic calcification, Current drug targets, 2008, 9 (3), 224-8.
Morony Sean, Tintut Yin, Zhang Zina, Cattley Russell C, Van Gwyneth, Dwyer Denise, Stolina Marina, Kostenuik Paul J, Demer Linda L, Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice, Circulation, 2008, 117 (3), 411-20.
Huang Michael S, Sage Andrew P, Lu Jinxiu, Demer Linda L, Tintut Yin, Phosphate and pyrophosphate mediate PKA-induced vascular cell calcification, Biochemical and biophysical research communications, 2008, 374 (3), 553-8.
Demer Linda L, Tintut Yin, Vascular calcification: pathobiology of a multifaceted disease, Circulation, 2008, 117 (22), 2938-48.
Radcliff Kristen, Tang Tri-Bang, Lim Jina, Zhang Zina, Abedin Moeen, Demer Linda L, Tintut Yin, Insulin-like growth factor-I regulates proliferation and osteoblastic differentiation of calcifying vascular cells via extracellular signal-regulated protein kinase and phosphatidylinositol 3-kinase pathways, Circulation research, 2005, 96 (4), 398-400.
Tintut Yin, Abedin Moeen, Cho John, Choe Andrea, Lim Jina, Demer Linda L, Regulation of RANKL-induced osteoclastic differentiation by vascular cells, Journal of molecular and cellular cardiology, 2005, 39 (2), 389-93.
Tintut Yin, Morony Sean, Demer Linda L, Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivo, Arteriosclerosis, thrombosis, and vascular biology, 2004, 24 (2), e6-10.
Abedin Moeen, Tintut Yin, Demer Linda L, Mesenchymal stem cells and the artery wall, Circulation research, 2004, 95 (7), 671-6.
Hsiai Tzung K, Cho Sung K, Wong Pak K, Ing Michael H, Salazar Adler, Hama Susan, Navab Mohamad, Demer Linda L, Ho Chih-Ming, Micro sensors: linking real-time oscillatory shear stress with vascular inflammatory responses, Annals of biomedical engineering, 2004, 32 (2), 189-201.
Garfinkel Alan, Tintut Yin, Petrasek Danny, Boström Kristina, Demer Linda L, Pattern formation by vascular mesenchymal cells, Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 (25), 9247-50.
Demer Linda L, Tintut Yin, Mineral exploration: search for the mechanism of vascular calcification and beyond: the 2003 Jeffrey M. Hoeg Award lecture, Arteriosclerosis, thrombosis, and vascular biology, 2003, 23 (10), 1739-43.
Tintut Yin, Alfonso Zeni, Saini Trishal, Radcliff Kristen, Watson Karol, Boström Kristina, Demer Linda L, Multilineage potential of cells from the artery wall, Circulation, 2003, 108 (20), 2505-10.
Mody Nilam, Tintut Yin, Radcliff Kristen, Demer Linda L, Vascular calcification and its relation to bone calcification: possible underlying mechanisms, Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2003, 10 (2), 177-83.
Demer Linda L, Adipose rex: fat and fats that rule differentiation, Circulation research, 2002, 90 (3), 241-3.
Demer Linda L, Vascular calcification and osteoporosis: inflammatory responses to oxidized lipids, International journal of epidemiology, 2002, 31 (4), 737-41.
Bostrom, K. Tsao, D. Shen, S. Wang, Y. Demer, L. L. , Matrix GLA protein modulates differentiation induced by bone morphogenetic protein-2 in C3H10T1/2 cells, J Biol Chem, 2001, 276 (17), 14044-52.
Mody, N. Parhami, F. Sarafian, T. A. Demer, L. L. , Oxidative stress modulates osteoblastic differentiation of vascular and bone cells, Free Radic Biol Med, 2001, 31 (4), 509-19.