California NanoSystems Institute
CNSI
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Ichiro Nishimura, D.D.S., D.M.D., D.M.Sc.

   
Professor, Advanced Prosthodontics, Biomaterials and Hospital Dentistry, Dentistry, Weintraub Center for Reconstructive Biotechnology
Member, California NanoSystems Institute, Neuroengineering Training Program

Education:
Degrees:
D.D.S., Tokyo Dental College, Tokyo, Japan, 1981
D.M.D., Harvard School of Dental Medicine, Boston, MA, 1993
D.M.Sc., Harvard University, Cambridge, MA, 1986

Academic Experience:
Fellowships:
Harvard School of Dental Medicine, Postdoctoral Research Fellow, 1982-86

Honors and Awards:
National Institute of Dental and Craniofacial Research, Certificate of Appreciation, 2005
International Association for Dental Research, Distinguished Scientist Award, 2004
Harvard School of Dental Medicine, Distinguished Faculty Award, 1993
University of Manchester, UK, Turner-Newell Lectureship, 1995
Omicron Kappa Upsilon Dental Society, 1990

Professional Societies:
Innovation and Research Management for Young Scientists

Certifications:
Certification Type:
Harvard Medical School, Research Associate, Department of Anatomy and Cellular Biology, 1986-88
UCLA School of Engineering and Applied Science, Faculty Advisory Board, the UCLA Biomedical Engineering Program, 1998-00
Health Science Technology, Harvard University & Massachusetts Institute of Technology, Program Director, Harvard/MIT Program for Biomaterials Science, 1993-95
Harvard School of Dental Medicine, Associate Professor and Director, Laboratory of Reconstructive Biotechnology, 1994-97
UCLA School of Dentistry, Director, The Weintraub Center for Reconstructive Biotechnology, 1997-02, 08-12
Harvard School of Dental Medicine and Beth Israel Deaconess Medical Center, Co-Director, Center for Reconstructive Biomedicine and Technology, 1996-97
Harvard Medical School, Faculty Member, Committee of Cell & Developmental Biology, 1990-93
Harvard School of Dental Medicine, Assistant Professor, Department of Prosthetic Dentistry, 1988-94
Harvard School of Dental Medicine, Director of Predoctoral Research Program, 1995-97
UCLA School of Dentistry, Professor, Division of Advanced Prosthodontics and Division of Oral Biology & Medicine, 1999-Present
UCLA School of Engineering and Applied Science, Affiliate Professor and Co-Director of NeuroEngineering, Department of Bioengineering, 2012-Present
UCLA School of Dentistry, Associate Professor, Division of Advanced Prosthodontics, 1997-99
American Association for Dental Research, Distinguished Service Award, 1999
Certification Type:
AAFP, Chairman, Tylman Research Award Committee, 1992-94
National Science Foundation, Grant reviewer, Metabolic Biochemistry Program, 1995
The International Journal of Oral Biology, Editorial Board (U.S. Academy Member), 1995-00
AAAS Section R: Dental and Oral Biology, Member-at-Large, 2013-17
Tokyo Dental College, Chiba, Japan, Extramural Advisor, The Oral Health Science Center, 1996-Present
California Dental Association, Council on Dental Research & Development, 2004-Present
IADR, Distinguished Scientist Award Committee (Chair, 08-09), 2004-09
Biotechnology and Biological Sciences Research Council (BBSRC), UK, Grant reviewer, 1995
UCLA Academic Senate, Chair, Councilor of Research, 2002-03
The Journal of Dental Research, Editorial Board, 1995-98
AAAS, Electorate Nominating Committee, 2007-10

Contact Information:
Work Email Address: inishimura@dentistry.ucla.edu
Work Address: 10833 Le Conte Ave
Los Angeles, CA 90095
UNITED STATES
Home Page: http://www.dentistry.ucla.edu/about-us/faculty/nishimura
Group Home Page Redirect: http://www.weintraub.dent.ucla.edu/people/pi/nishimura/
Work Phone Number: (310) 794-7612
Technical Research Interest:

Recent and Current Projects
  • Post-transcriptional mRNA abnormality in painful neuropathy
  • NeuroEngineering of composite face transplantation
  • Innate Immunity in oral mucosa barrier and transplant tissue rejection
  • Oral mucosa barrier and bisphosphonate-related osteonecrosis of the jaw
  • Mechanism of Clastokine Regulation in Osteoclasts and Tumor Metastasis
  • Peripheral “Circadian Molecular Clock” and successful implant osseointegration
  • Accelerated wound closure devised by fibroblasts expressing wound inducible transcript (wit3.0): A drug screening project



Additional Information:

Nishimura received his dental training at the Tokyo Dental College and the Harvard School of Dental Medicine. His advanced research education at Harvard resulted in the Doctor of Medical Sciences (DMSc) degree in 1986. After a postdoctoral research in cellular and molecular biology under Professor Bjorn Olsen at the Harvard Medical School, Nishimura became a principal investigator of tissue regeneration research supported by federal and industry grants. He has served as Director of the Harvard-MIT Biomaterials Research Training Program (1993-95), Director of Predoctoral Research Program at the Harvard School of Dental Medicine (1995-97), and Co-Director of the Harvard-BIDMC Center for Reconstructive Biomedicine and Technology (1996-97). He joined UCLA in 1997 and established the Jane and Jerry Weintraub Center for Reconstructive Biotechnology, which is supported by the National Center for Research Resources and philanthropic contributions from film and entertainment industry. He is a Professor in the Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry of the UCLA School of Dentistry, and a member of the Advisory Board of the Biomedical Engineering Program, UCLA School of Engineering and Applied Science.

Selected Publications:

Armin BB, Hokugo A, Nishimura I, Tamplen M, Beumer J 3rd, Steinberg ML, Abemayor E, Nabili V, Brachytherapy-mediated bone damage in a rat model investigating maxillary osteoradionecrosis, Arch Otolaryngol Head Neck Surg, 2013, 38 (2), 167-71.
Hokugo A, Sun S, Park S, McKenna C, Nishimura I, Equilibrium-dependent bisphosphonate interaction with crystalline bone mineral explains the anti-resorptive pharmacokinetics and the prevalence of osteonecrosis of the jaw in a rat model, Bone, 2013, 53 (1), 59-68.
Ha J, Osher SJ, Nishimura I, Mathematical filtering minimized metallic halation of titanium implant in microCT image, J Cal Dent Assoc, 2013, 41 (1), 41-5.
Cheng W, Nishimura I, High throughput screening of biologically functional small molecules for modulating the expression of FGFR1OP2/wit3.0 in fibroblasts, J Calif Dent Assoc, 2012, 40 (12), 929-31, 934-7.
Kahenasa N, Sung E, Nabili V, Kelly J, Garret N, Nishimura I, Resolution of pain and complete healing of mandibular osteoradionecrosis using pentoxifylline and tocopherol, a case report, Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol, 2012, 113 (4), e18-e23.
Suwanwela J, Lee J, Lin A, Ucer C, Devlin H, Sinsheimer J, Garrett N, Nishimura I, A Genetic Association Study of Single Nucleotide Polymorphisms in FGFR1OP2/wit3.0 and Long-term Atrophy of Edentulous Mandible, PloS One, 2011, 6 (1), e16204.
Mawardi H, Giro G, Kajiya M, Ohta K, Almazrooa S, Alshwaimi E, Woo S-B, Nishimura I, Kawai T, A role of oral bacteria in bisphosphonate-induced osteonecrosis of jaw, J Dent Res, 2011, 90 (11), 1339-45.
Honda Y, Ding X, Mussano F, Wiberg A, Ho CM, Nishimura I, Application of feedback system control (FSC) to identify the optimized osteogenic drug cocktails, IEEE, 2011.
Ruangsri S, Lin A, Mulpuri Y, Lee K, Spigelman I, Nishimura I, Axonal Nav1.8 mRNA accumulation and sciatic nerve injury-induced painful neuropathy in rats, J Biol Chem, 2011, 286 (46), 39836-47.
Mengatto CM, Mussano F, Honda Y, Colwell C, Nishimura I, Circadian rhythm and cartilage extracellular matrix genes in osseointegration: A genome-wide screening of implant failure by vitamin D deficiency, PloS One, 2011, 6 (1), e15848.
Mussano F, Lee K, Zuk P, Tran L, Cacalano N, Jewett A, Carossa S, Nishimura I, Differential effect of ionizing radiation exposure on multipotent and differentiation-restricted bone marrow mesenchymal stem cells, J Cell Biochem, 2010, 111 (2), 322-32.
Hokugo A, Christensen R, Chung E, Sung E, Felsenfeld AL, Sayer J, Garrett N, Adams JS, Nishimura I, Increased prevalence of bisphosphonate-related osteonecrosis of the jaw with vitamin D deficiency in rats, J Bone Min Res, 2010, 25 (6), 1337-49.
Lin A, Hokugo A, Choi J, Nishimura I, Small coiled-coil cytoskeleton-associated molecule, FGFR1OP2/wit3.0 facilitates fibroblast-driven wound closure, Am J Pathol, 2010, 176 (1), 108-121.
Thakor DK, Lin A, Matsuka Y, Meyer E, Ruangsri S, Nishimura I, Spigelman I, Neuropathy-induced upregulation of peripheral nerve excitability and Nav1.8 mRNA expression, Mol Pain, 2009, 5 (1), 14.
Wang CJ, Iida K, Egusa H, Hokugo A, Jewett A, Nishimura I, Trabecular bone deterioration in col9a1+/- mice associated with enlarged osteoclasts adhered to collagen IX-deficient bone, J Bone Min Res, 2008 (23), 837-849.
Nishimura I, Huang Y, Butz F, Ogawa T, Lin A, Wang CJ, Discrete deposition of hydoroxyapatite nano-particles on titanium implant with predisposing substrate micro-topography accelerated osseointegration, Nanotechnology, 2007 (18), 245101 (9pp).
Egusa H, Iida K, Kobayashi M, Lin T, Zhu M, Zuk P, Hedrik M, Nishimura I, Down-regulation of extracellular matrix-related gene cluster during osteogenic differentiation of bone marrow and adipose tissue-derived stromal cells, Tissue Eng, 2007 (13), 2589-2600.
Thakor D, Spigelman I, Tabata Y, Nishimura I, Subcutaneous peripheral injection of cationized gelatin/DNA polyplexes as a platform for noninvasive gene transfer to sensory neurons, Molecular Therapy, 2007 (15), 2124-2131.
Lee D, Yuki I, Murayama Y, Nishimura I, Vinters HV, Chiang A, Wang CC, Nien YL, Ishii A, Vinuela F, Thrombosis and healing in the experimental aneurysm model, part I: A histological and molecular analysis of thrombus organization and healing in the swine experimental aneurysm model, J Neurosurg, 2007 (107), 94-108.
Egusa H, Schweizer FE, Wang C-C, Matsuka Y, Nishimura I, Neuronal Differentiation of Bone Marrow-Derived Stromal Stem Cells Involves Suppression of Discordant Phenotypes through Gene Silencing, J Biol Chem , 2005 (280), 23691-23697.