California NanoSystems Institute
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Louis Bouchard, Ph.D.

Assistant Professor, Biophysics and Structural Biology, Chemistry and Biochemistry, Nanoscience and Materials, Physical, Physical Chemistry
Member, California NanoSystems Institute, JCCC Cancer and Stem Cell Biology Program Area, Jonsson Comprehensive Cancer Center

Ph.D., Princeton University, Princeton, NJ, 2005
M.A., Princeton University, Princeton, NJ, 2003
M.S., University of Toronto, Toronto, Canada, 1999
B.S., McGill University Montr´eal, Canada, 1996

Contact Information:
Email Address:
Work Email Address:
Laboratory Address: Young Hall 2104 and 2042
Laboratory Address: Student Office: Young Hall 3085
Work Address: Department of Chemistry and Biochemistry
607 Charles E Young Dr East / Young Hall 3048B
University of California, Los Angeles, CA 90095
Home Page:
Work Phone Number: 1 (310) 825-1764 Office
Research Interests:

Our laboratory is developing novel functionalized magnetic nanoparticles with unique physical properties for multi-modality targeted molecular imaging via MRI, PET, CT and optical methods. We are interested in all aspects of the research including chemical synthesis, characterization, detection and clinical trials of cancer-related problems. In a second project, we are developing novel optical methods for nanoscale imaging and the study of surface magnetism in metal clusters and high-Tc superconducting materials. Both projects require the active involvement of multiple collaborators and experts in several disciplines (physics, chemistry, engineering, biochemistry and biomedicine).

Selected Publications:

Bouchard LS, Acosta VM, Bauch E, Budker D, Detection of the Meissner effect with a diamond magnetometer, New J. Phys, 2011, 13, 025017.
Sharma R, Taylor RE, Bouchard LS, Intramolecular Ligand Dynamics in d15-(PPh3)-Capped Gold Nanoparticles Investigated by 2H NMR, The Journal of Physical Chemistry C, 2011, 115 (8), 3297-3303.
Michalak DJ, Xu S, Lowery TJ, Crawford CW, Ledbetter M, Bouchard LS, Wemmer DW, Budker D, Pines A, Relaxivity of Gadolinium Complexes Detected by Atomic Magnetometry, Magn. Reson. Med, 2011, Epub ahead of print.
Robson SA, Peterson R, Bouchard LS, Villareal VA, Clubb RT, Heteronuclear Zero Quantum Coherence Nz-Exchange Experiment That Resolves Resonance Overlap and Its Application To Measure the Rates of Heme Binding to the IsdC Protein, J. Am. Chem. Soc, 2010, 132 (28), 9522-9523.
Acosta VM, Bauch E, Ledbetter MP, Waxman A, Bouchard LS, Budker D, Temperature dependence of the nitrogen-vacancy magnetic resonance in diamond, Phys. Rev. Lett, 2010, 104, 070801.
McFadden C, Bouchard LS, Universality of Cluster Dynamics, Physical Review E, 2010, 82 (6 Pt. 1), 061125.
Bouchard LS, "Shimming pulses" in Magnetic Resonance Microscopy: Spatially Resolved NMR Techniques and Applications, Wiley-VCH, 2009, Ed. Joseph D. Seymour and Sarah Codd.
Demas V, Franck JM, Bouchard LS, Sakellariou D, Meriles CA, Martin R, Prado PJ, Bussandri A, Reimer JA, Pines A, 'Ex-Situ' magnetic resonance volume imaging, Chemical Physics Letters, 2009, 467, 398-401.
Kelso N, Lee SK, Bouchard LS, Demas V, Muck M, Pines A, Clarke JC, Distortion-Free Magnetic Resonance Imaging in the Zero-Field Limit, Journal of Magnetic Resonance, 2009, 200, 285-290.
Bouchard LS, Anwar MS, Liu GL, Hann B, Xie H, Gray JW, Wang X, Pines A, Chen FF, Picomolar Sensitivity MRI and Photoacoustic Imaging of Cobalt Nanoparticles, Proc. Natl. Acad. Sci. USA, 2009, 106, 4085-4089.
Franck JM, Demas V, Martin RW, Bouchard LS, Pines A, Shimmed matching pulses: Simultaneous control of rf and static gradients for inhomogeneity correction, Journal of Chemical Physics, 2009, 131, 234506.
Paulsen JL, Franck J, Demas V, Bouchard LS, Least squares magnetic-field optimization for portable nuclear magnetic resonance magnet design, IEEE Transactions on Magnetics, 2008, 44, 4582-4590.
Bouchard LS, Burt SR, Anwar MS, Kovtunov KV, Koptyug IV, Pines A, NMR imaging of catalytic hydrogenation in microreactors with the use of parahydrogen, Science , 2008, 319, 442–445 .
Bouchard LS, Sushkov AO, Budker D, Ford JJ, Lipton AS, Nuclear-spin relaxation of 207Pb in ferroelectric powders, Physical Review A, 2008, 77, 022102.
Verpillat F, Ledbetter MP, Budker D, Xu S, Michalak M, Hilty C, Bouchard LS, Antonijevic S, Pines A, Remote detection of nuclear magnetic resonance with an anisotropic magnetoresistive sensor , Proc. Natl. Acad. Sci. USA, 2008, 105, 2271–2273 .
Paulsen JL, Bouchard, LS, Graziani N, Bluemich B, Pines A, Volume selective magnetic resonance imaging using an adjustable, single-sided, portable sensor, Proc. Natl. Acad. Sci. USA, 2008, 105, 20601-20604.
Jachmann RC, Trease D, Bouchard LS, Sakellariou D, Martin R, Schlueter RD, Budinger, TF, Pines A , Multipole shimming of permanent magnets using harmonic corrector rings, Review of Scientific Instruments , 2007, 78, 035115.
Bouchard LS, Kovtunov KV, Burt SR, Anwar MS, Koptyug IV, Sagdeev RZ, Pines A, Parahydrogen-enhanced gas-phase magnetic resonance imaging, Angewandte Chemie Intl Ed , 2007, 46, 4064–4068 (ranked Very Important Paper).
Anwar MS, Hilty C, Chu C, Bouchard LS, Pierce KL, Pines A, Spin coherence transfer in chemical transformations monitored by remote detection NMR, Analytical Chemistry , 2007, 79, 2806–2811 .
Bouchard LS, Anwar MS, Synthesis of matched magnetic fields for controlled spin precession, Physical Review B , 2007, 76, 014430 .
Bouchard LS, Unidirectional magnetic-field gradients and geometric-phase errors during Fourier encoding using orthogonal ac fields, Physical Review B , 2006, 74, 054103 .
Bouchard LS, Warren WS, Multiple-quantum vector field imaging by magnetic resonance, J. Magn. Reson, 2005, 177 (1), 1-13.
Bouchard LS, Wehrli FW, Chin CL, Warren WS, Structural anisotropy and internal magnetic fields in trabecular bone: coupling solution and solid dipolar interactions, J. Magn. Reson, 2005, 176 (1), 27-36.
Ledbetter MP, Savukov IM, Bouchard LS, Romalis MV, , Numerical and experimental studies of long-range magnetic dipolar interactions, J. Chem. Phys. , 2004, 121, 1454-65.
Tang XP, Chin CL, Bouchard LS, Warren WS, Wehlri FW, Observing Bragg-like diffraction via multiple coupled nuclear spins, Phys. Lett. A, 2004, 326, 114-25.
Bouchard LS, Warren WS, Reconstruction of porous material geometry by stochastic optimization based on NMR measurements of the dipolar field, J. Magn. Reson, 2004, 170, 299-309.
Shannon KL, Branca RT, Galiana G, Cenzano S, Bouchard LS, Soboyejo W, Warren WS, Simultaneous acquisition of multiple orders of intermolecular multiple-quantum coherence images in vivo, Magn. Reson. Imaging, 2004, 22, 1407-12.
Bouchard LS, Warren WS , Tensorial character of magnetization diffusion in periodic lattices, Phys. Rev. B, 2004, 70 (224426).
Chin CL, Tang XP, Bouchard LS, Saha PK, Warren WS, Wehrli FW, Isolating quantum coherences in structural imaging using intermolecular double-quantum coherence MRI, J. Magn. Reson, 2003, 165 (2), 309-14.
Bouchard LS, Rizi RR, Warren WS, Magnetization structure contrast based on intermolecular multiple-quantum coherences, Magn. Reson. Med. , 2002, 48, 972-9.
Bouchard LS, Bronskill MJ, Magnetic resonance imaging of thermal coagulation effects in a phantom for calibrating thermal therapy devices , Med. Phys, 2000, 27, 1141-5.
Youssef K, Mack JJ, Iruela-Arispe ML, Bouchard LS, Macro-scale Topology Optimization for Controlling Internal Shear Stress in a Porous Scaffold Bioreactor, (submitted), 2011.
Sharma R, Bouchard LS, Maximally hyperpolarized gas from parahydrogen by rational design of ligand-capped nanoparticles, (submitted) .
Taylor RE, Alyahyaei HM, Wang Z, Shi J, Wang KL, Bouchard LS, 77Se NMR Investigation of Fe0.05Bi1.95Se3, .
Compton R, Osher S, Bouchard L, Hybrid regulatization for MRI reconstruction with field inhomogeneity correction, (submitted) .
Paulsen Jeffrey L, Bouchard Louis S, Graziani Dominic, Blümich Bernhard, Pines Alexander, Volume-selective magnetic resonance imaging using an adjustable, single-sided, portable sensor, Proceedings of the National Academy of Sciences of the United States of America, 2008, 105 (52), 20601-4.
Soulez Gilles, Therasse Eric, Giroux Marie-France, Bouchard Louis, Gilbert Patrick, Perreault Pierre, Cloutier Guy, Oliva Vincent L, Management of peripheral arterial disease: role of computed tomography angiography and magnetic resonance angiography, Presse médicale (Paris, France : 1983), 2011, 40 (9 Pt 2), e437-52.