California NanoSystems Institute
CNSI
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John McDonald, M.D.

   
Professor of Anesthesiology, David Geffen School of Medicine at UCLA, Anesthesiology
Professor of Obstetrics and Gynecology Harbor-UCLA Medical Center, Department of Obstetrics and Gynecology
Professor of Anesthesiology Harbor-UCLA Medical Center, Department of Anesthesiology
Member, California NanoSystems Institute

Education:
Degrees:
M.D., University of Iowa College of Medicine, Iowa City, Iowa, 1960 - 1964
B.A., University of Iowa, Iowa (Nile Kinnick Scholar), 1956 - 1960

Honors and Awards:
2008 The Smithsonian Institution, Laureate Medal Ceremony
1996 The Smithsonian Institution, Cray Research Leadership Award for Computational Science

Education:
Residency:
1968 - 1970 University of Washington, Seattle, Washington, Department of Anesthesiology
1965 - 1968 University of Iowa College of Medicine, Iowa City, Iowa, Department of Obstetrics & Gynecology

Academic Experience:
Academic Experience:
1964 - 1965 University of Oregan, Portand, Oregon, Internship

Contact Information:
Email Address: jsm5525@ucla.edu
Work Address: Harbor/UCLA Medical Center
Department of Anesthesiology
1000 West Carson Street
Box #10
Torrance, CA 90502
UNITED STATES
Fax Number: (310) 222-5252 Fax
Work Phone Number: (310) 222-5240 Office
Research Interests:

  • Pelvic pain of men & women – diagnosis & treatment
  • Research pain regarding facilitation and transmission
  • Sub cellular exploration of local anesthetic effect
  • Sympathetic network involvement in pain
  • Ropivacaine effect on mitochondria of the DRG



Additional Information:

Dr. John McDonald received his M.D. from the University of Iowa in 1964. He completed internship at the University of Oregon in 1965. He completed an Ob/Gyn residency at the University of Iowa in 1968. He completed his second residency in Anesthesiology at the University of Washington in 1970.

His first academic position was at LAC/USC from 1970-1977 as Assistant Professor of Anesthesiology and Obstetrics and Gynecology. He co-founded the first neonatal intensive care unit at LAC/USC and was also director of anesthesiology and Respiratory Therapy at Women’s Hospital.

His second academic position was the University of Colorado as Professor and Vice Chairman of Anesthesiology and Professor of Obstetrics and Gynecology 1977-1978.

His third academic appointment was at The Ohio State University as Professor and Chairman of Anesthesiology and Professor of Obstetrics and Gynecology 1978-1998.

He was also appointed as faculty at the Ohio Super-Computer Center 1988.

His fourth academic appointment is at Los Angeles where he is Professor and Chairman of Anesthesiology and Professor of Obstetrics and Gynecology both at Harbor-UCLA Medical Center and David Geffen School of Medicine at the University of California at Los Angeles.

Dr. McDonald was recruited by founder of the Ohio Supercomputer Center, Dr. Charlie Bender; who believed his presence as faculty would stimulate ideas from the medical viewpoint that would be fresh projects for research and development of new viewpoints of model formulation. This became reality within the next few years with the development of the model of "Virtual Reality Lumbar Epidural". This provided Dr. McDonald and colleague Don Stredney’s development of an end product that later precipitated their receiving a Smithsonian Award at the 1996 annual Washington D.C. ceremony.

Recent research efforts have focused on development of a unique research group composed of a total of five M.D.s and Ph.D.s. Our work continues to be centered about the confocal scope with the academic focus on pain messaging systems of the rat pelvis bladder, uterus, and colon. Our group has published 4 peer review papers in the past five year period.

Our current focus is development of unraveling of the mystery of pain as it concerns the "intracellular mechanisms". We believe some of the quandary of inconsistent relief of pelvic pain lies in this medium and we plan to continue our search for some means of understanding this enigmatic major pain problem.



Selected Publications:

Chaban V, Li J, McDonald JS, Rapkin A, Micevych P, Estradiol attenuates ATP- induced increase of intracellular calcium through group II metabotropic glutamate receptors in rat DRG neurons, J Neurosci Res, 2011, 89 (11), 1707-10.
Weiss IK, Isenberg SJ, McArthur DL, Del Signore M, McDonald JS, Monitoring the Conjunctiva for Carbon Dioxide and Oxygen Tensions and pH During Cardiopulmonary Bypass, The Journal of ExtraCorporeal Technology, 2011, 43, 13-18.
Kakazu CZ, Kwan WF, Chen BJ, McDonald JS, More on perfusion index and its use as a maternal monitor for fetal well being, Pediatr Crit Care Med, 2009, 10 (1), 144-5.
Li J, Micevych P, McDonald JS, Rapkin A, Chaban V, Inflammation in the uterus induces pERK ans Substance P activation in DRG neurons innervating both uterus and colon in rats, Journal of Neuroscience Research, 2008, 86 (12), 2746-52.
Rapkin AJ, McDonald JS, Morgan M, Multilevel local anesthetic nerve blockade for the treatment of vulvar vestibulitis syndrome, Am J Obstet Gynecol, 2008, 198 (1), 41-2.
Chaban V, Christensen A, Wakamatsu M, McDonald M, Rapkin A, Micevych P, McDonald JS, The same dorsal root ganglion neurons innervate uterus and colon in the rat, NeuroReport, 2007, 18 (3), 209-12.
McDonald JS, Spigos, Dimitris, CT Guided Pudendal Block for Pudendal Pain, Obstetrics and Gynecology, 2000, 95 (2), 306-9.
McDonald JS, Computer driven needle probe enables therapy for painful neuropathies, Stud Health Technol Inform, 2000, 70, 202-6.
McDonald JS, Yagel R, Schmalbrock P, Stredney D, Reed DM, and DJ Sessanna, Visualization of compression neuropathies through volume visualization, Proceedings of Medicine Meets Virtual Reality, 1997, 99-106.
Stredney D, Sessanna D, McDonald JS, Hiemenz L, Rosenberg LB, A virtual simulation environment for learning epidural anesthesia, Stud Health Technol Inform, 1996, 29, 164-75.
Allard J, Dzwonczyk R, Yablok D, Block FE Jr., McDonald JS, Effect of automatic record keeping on vigilance and record keeping time, Br J Anaesth, 1995, 74 (5), 619-26.
McDonald JS, Kuperwasser B, Nunziata E, Vavuranakis M, Boudoulas H, Effect of anesthesia on diastolic time and the relationship between electrical and electromechanical systole, Hellenic J Cardiol, 1994, 35, 145-150.
Myung HK, Stokes, BT, McDonald JS, Procaine, lidocaine, and hypothermia inhibit calcium paradox in cells, Anesth Analg, 1994, 79, 728-33.
McDonald JS, Liandngam RP, Gupta B, Jacoby J, Gough HG, Bradley P, Psychologic testing as an aid to selection of residents in anesthesiology, Anesth Analg, 1994, 78, 542-7.
Tejwani GA, Rattan AK, Sribanditmongkol P, Sheu MJ, Zuniga J, McDonald, Inhibition of Morphine - Induced Tolerance and Dependence by a Benzodiazepine Receptor Agonist Midazolam in the Rat, Anesth Alang, 1993 (76), 1052-1060.
Jurkowitz-Alexander MS, Altschuld RA, Hohl CM, Johnson JD, McDonald JS, Simmons TD, Horrocks LA:, Cell swelling, blebbing, and death are dependent on ATP depletion and independent of calcium during chemical hypoxia in the glial cell line (ROC-1), J Neurochem, 1992 (59), 344.
Tejwani GA, Rattan AK, McDonald JS:, Role of spinal opioid receptors in the antinociceptive interactions between intrathecal morphine and bupivacaine, Anesth Alang, 1992 (74), 726.
Cook RI, Potter SS, Woods DD, McDonald JS, Evaluating the human engineering of microprocessor-controlled operating room devices, J Clin Monit, 1991 (7), 217.
Tejwani GA, Rattan AK, Gudehithlu KP, McDonald JS, Modulation of mu, kappa and delta opoid receptors in the rat brain by isoflurane and enflurane, Neuropharmacology, 1991 (30), 643.
Gough HG, Bradley P, McDonald JS:, Performance of residents in anesthesiology as related to measures of personality and interests, Psych Reports, 1991 (63), 979.
Cook RI, McDonald JS, Nunziata E:, Differences between handwritten and automatic blood pressure records, Anesthesiology, 1989 (71), 385.
Dzwonczyk R, Howie MB, McDonald JS, A comparison between Walsh and Fourier analysis of the electroencephalogram for tracking the effects of anesthesia, IEEE trans on Biomed Eng, 1984, BME 31.
Valenzuela WR, Klinger A, McDonald JS, Fetal Heart rate Pattern recognition, IEEE trans on Biomed Eng, 1975 (BME-22:18).
McDonald JS , Anesthesia for operative obstetrics, Proceedings of the 5th World Congress of Anesthesiology, 1972.
McDonald JS, Siassi B, Hon E, Hodgman JE:, Cardiovascular effects of apnea in premature infants, Ped Res, 1972 (6), 405.
McDonald JS, Mateo CV, Reed EC:, Modified nitrous oxide or ketamine hydrochloride for cesarean sectino, Anest Analg, 1972 (51), 975.
McDonald JS, Fetal Distress, Obstetrics and Gynecology Collected Letters, 1968 (9), 31.
Mc Donald JS, Evaluation of fetal blood pH as reflection of fetal well being, Am J Obstet Gynecol, 1967 (97), 912.
Zellweger H, McDonald JS, Abbo G, Is lysergic-acid diethylamide a teratogen, Lancet, 1967 (2), 1066.
Zellweger H, McDonald JS, Abbo G, Is lysergide a teratogen, Lancet, 1967 (2), 1306.
Hamilton WK, McDonald JS, Fisher HW, Berthards R, Postoperative respiratory complications, Anesthesiology, 1967 (25), 607.
Laughlin DE, McDonald JS, Bedell GE, A microtechnique for measure of pO2 in "arterialized" earlobe blood, J Lab Clin Med, 1964, 64 (330).
McDonald JS, Laughlin DD, Bedell GE, Direct approach to evaluation of patients with acid-base imbalance, JAMA, 1964, 188 (9).