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Kathleen Kelly, Ph.D.

   
Technical Director, Clinical Chemistry
Professor, Pathology and Laboratory Medicine
Member, California NanoSystems Institute
Faculty, Cellular and Molecular Pathology PhD Program

Education:
Degrees:
Ph.D., Ohio State University, 1990
B.S., Ohio State University, 1983

Honors and Awards:
2003 Association of Clinical Scientists, Young Clinical Scientist Award
2000 College of Medicine, UCLA, Frontiers in Science Award
1994 Academy of Clinical Laboratory Physicians and Scientists Young Investigator Award
1992 Academy of Clinical Laboratory Physicians and Scientists Young Investigator Award
1986 - 1990 Department of Medical Microbiology & Immunology, Ohio State University, Graduate Research Award

Academic Experience:
Academic Experience:
1996 Univ. of Arkansas for Med. Sci., Reproductive Immunology
1990 - 1995 Washington University, Immunology

Contact Information:
Email Address: kkelly@mednet.ucla.edu
Laboratory Address: Laboratory
Department of Pathology & Lab. Medicine
Mailroom A7-142 CHS
mailcode 173216
Los Angeles, CA 90095
UNITED STATES
Work Address: Office
Department of Pathology & Lab Medicine
Mailroom A7-149 CHS
mailcode 173216
Los Angeles, CA 90095
UNITED STATES
Home Page: http://faculty.pathology.ucla.edu/institution/personnel?personnel_id=45971
Work Phone Number: (310) 206-4910 Laboratory
310-206-5562 Office
Additional Information:

Kathleen Kelly is an Associate Professor who joined the Department of Pathlogy and Lab Medicine in 1999. Dr. Kelly earned her B.S. in Medical Technology and PhD in Immunology at the Ohio State University in Columbus, Ohio. She was a postdoctoral fellow at Washington University in St. Louis, where she worked on the role of T cell subsets in germinal center formation. She then served as a junior faculty member in the Department of Microbiology and Immunology at the Unviersity of Arkansas for Medical Sciences. She focused on mucosal immunology and concentrated her studies on immune responses in the reproductive tract. Dr. Kelly is actively involved in graduate, undergraduate and medical student education. She is a recipient of the Young Scientist Award and past chair of the Immunology Division for the American Society of Microbiology.

Selected Publications:

Kar Upendra K, Jiang Janina, Champion Cheryl I, Salehi Sahar, Srivastava Minu, Sharma Sherven, Rabizadeh Shahrooz, Niazi Kayvan, Kickhoefer Valerie, Rome Leonard H, Kelly Kathleen A, Vault Nanocapsules as Adjuvants Favor Cell-Mediated over Antibody-Mediated Immune Responses following Immunization of Mice, PloS one, 2012, 7 (7), e38553.
Jiang Janina, Kelly Kathleen A, Phenotype and function of regulatory T cells in the genital tract, Current trends in immunology, 2011, 12 (1), 89-94.
Moniz, R.J. Chan, A.M., Gordon, L.K., Braun, J., Arditi, M., Kelly, K.A., Plasmacytoid dendritic cells modulate non-protective T cell responses to genital infection by C. muridarum, FEMS Immunol Med Microbiol, 2010, 58 (3), 397-404.
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King M, Poya H, Rao J, Natarajan S, Butch AW, Aziz N, Kok S, Chang MH, Lyons JM, Ault K, Kelly KA, CXCL13 expression in Chlamydia trachomatis infection of the female reproductive tract, Drugs Today (Barc), 2009, 45 (Supplement B), 125-34.
Moniz Raymond J, Chan Ann M, Kelly Kathleen A, Identification of dendritic cell subsets responding to genital infection by Chlamydia muridarum, FEMS immunology and medical microbiology, 2009, 55 (2), 226-36.
Abdul-Sater, A.A., Saïd-Sadier, N., Ojcius, D.M., Yimaz, Ö, Yimaz and Kelly, K.A., Infammasomes Bridge Signaling Between Pathogen Identification and the Immune Response, Drugs of Today, 2009, 45, 96-104.
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Kelly KA, Wiley, D, Butch, A, Wiesmeier, E, Briskin, M and Darville, T. , The combination of α4β7 and selectin ligand enhances T cell migration to the reproductive tract during bacterial infection. , Am J Reprod Immunol, 2009, 6, 446-452.
Kelly, KA, Chan, A.M., Butch, A.W. and Darville, T. , Two different homing pathways involving integrin β7 and E-selectin significantly influence trafficking of CD4 cells to the genital tract following C. muridarum infection. , Am J Reprod Immunol, 2009, 61 (6), 438-445.
Kelly, Wiley, Wiesmeier, Briskin, Butch, Darville, The Combination of the Gastrointestinal Integrin (alpha4beta7) and Selectin Ligand Enhances T-Cell Migration to the Reproductive Tract During Infection with Chlamydia trachomatis, American journal of reproductive immunology, 2009, Epub ahead of print.
Shimazaki Kaori, Chan Ann M, Moniz Raymond J, Wadehra Madhuri, Nagy Agnes, Coulam Catherine P, Mareninov Sergey, Lepin Eric M, Wu Anna M, Kelly Kathleen A, Braun Jonathan, Gordon Lynn K, Blockade of epithelial membrane protein 2 (EMP2) abrogates infection of Chlamydia muridarum murine genital infection model, FEMS immunology and medical microbiology, 2009, 55 (2), 240-9.
Champion Cheryl I, Kickhoefer Valerie A, Liu Guangchao, Moniz Raymond J, Freed Amanda S, Bergmann Liisa L, Vaccari Dana, Raval-Fernandes Sujna, Chan Ann M, Rome Leonard H, Kelly Kathleen A, A vault nanoparticle vaccine induces protective mucosal immunity, PloS one, 2009, 4 (4), e5409.
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Kickhoefer Valerie A, Han Muri, Raval-Fernandes Sujna, Poderycki Michael J, Moniz Raymond J, Vaccari Dana, Silvestry Mariena, Stewart Phoebe L, Kelly Kathleen A, Rome Leonard H, Targeting vault nanoparticles to specific cell surface receptors, ACS nano, 2009, 3 (1), 27-36.
Kaori Shimazaki, Ann M. Chan, Raymond J. Moniz, Eric M. Lepin, Agnes Nagy, Paige Coulum, Sergey Mareninov, James D. Marks, Anna M. Wu, Kathleen A. Kelly, Jonathan Braun and Lynn K. Gordon., Blockade of epithelial membrane protein 2 (EMP2) abrogates infection of Chlamydia muridarum (MoPn) murine genital infection model, FEMS Immunol Med Microbiol, 2008, 1574-695X.
Raymond J. Moniz, Chan, A.M. and Kelly, K., Identification of dendritic cell subsets responding to genital infection by Chlamydia trachomatis, FEMS Immunol Med Microbiol, 2008, 1574-695X.
Liu, W. Kelly, K. A., Prostaglandin E2 modulates dendritic cell function during chlamydial genital infection, Immunology, 2008, 123 (2), 290-303.
Kaori, S. Wadehra, M, Forbes, A., Kelly, K.A., Goodglick, L., Braun, J. and Gordo, L.K. , Epithelial membrane protein 2 modulates infectivity of Chlamydia muridarum (MoPn), Microbes Infect, 2007, 9, 1003-1010.
Liu, W. and Kelly, K.A., Postaglandin E2 modulates dendritic cell function during chlamydial genital infection. , Immunology, 2007, 123, 1365-2567.
Kelly Kathleen A, Butch Anthony W, Antigen-specific immunoglobulin E+ B cells are preferentially localized within germinal centres, Immunology, 2007, 120 (3), 345-53.
Liu, W. Dubinett, S. Patterson, S. L. Kelly, K. A., COX-2 inhibition affects growth rate of Chlamydia muridarum within epithelial cells, Microbes Infect, 2006, 8 (2), 478-86.
Kelly, K.A., Chapter 19:T lymphocyte trafficking to the female reproductive mucosae, In Chlamydia: Genomics, Pathogenesis and Implications for Control. Horizon Scientific Press, Norwick, UK, 2006, 413-433.
Kelly K.A. and Butch, A.W., Localization of antigen-specific IgE+ cells within germinal centers in a primary immune response to 2-phenyloxazolone, Immunology, 2006, 120, 346-353.
Welter-Stahl, L, Ojcius, D.M. Viala, J. Girardin, S. Liu, W, Delarbre, C. Philpott, D. Kelly, K.A. Darville, T. , Stimulation of the cytosolic receptor for peptidoglycan, Nod1, by infection with Chlamydia trachomatis or Chlamydia muridarum, Cell Microbiol, 2006, 8, 1047-57.
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Maxion, H. K. Liu, W. Chang, M. H. Kelly, K. A., The infecting dose of Chlamydia muridarum modulates the innate immune response and ascending infection, Infect Immun, 2004, 72 (11), 6330-40.
Kelly, K. A., Cellular immunity and Chlamydia genital infection: induction, recruitment, and effector mechanisms, Int Rev Immunol, 2003, 22 (1), 3-41.
Ault, KA Kelly, KA Ruther, PE Izzo, AA Izzo, LS Sigar, IM Ramsey, KH, Chlamydia trachomatis enhances the expression of matrix metalloproteinases in an in vitro model of the human fallopian tube infection, American journal of obstetrics and gynecology. , 2002, 187 (5), 1377-83.
Hawkins, R.A., Rank, R.G. and Kelly, K.A, A Chlamydia-specific Th2 clone induces antibody production but not protection against a genital infection, Infection and Immunity, 2002, 70, 5132-5139.
Maxion, H. K. Kelly, K. A., Chemokine expression patterns differ within anatomically distinct regions of the genital tract during Chlamydia trachomatis infection, Infect Immun, 2002, 70 (3), 1538-46.
Maxion, H.K. and Kelly, K.A, Differential chemokine expression in distinct regions of the murine gential tract in response to infection with Chlamydia trachomatis, Infection and Immunity, 2002, 70, 1538-1546.
Kelly, K. A. Natarajan, S. Ruther, P. Wisse, A. Chang, M. H. Ault, K. A., Chlamydia trachomatis infection induces mucosal addressin cell adhesion molecule-1 and vascular cell adhesion molecule-1, providing an immunologic link between the fallopian tube and other mucosal tissues, J Infect Dis, 2001, 184 (7), 885-91.
Kelly, K. A. Gray, H. L. Walker, J. C. Rank, R. G. Wormley, F. L., Jr. Fidel, P. L., Jr., Chlamydia trachomatis infection does not enhance local cellular immunity against concurrent Candida vaginal infection, Infect Immun, 2001, 69 (5), 3451-4.
Kelly, K.A., Natarajan, S., Ruther, P., Wisse, A., Chang, M-H and Ault, K., Chlamydia trachomatis infection induces Mucosal Addressin Cell Adhesion Molecule-1 (MAdCAM-1) and CD106 providing and immunological link between the fallopian tube and other mucosal tissues, J. Inf. Dis, 2001, 184, 885-891.
Butch, A. W. Kelly, K. A. Munshi, N. C., Dendritic cells derived from multiple myeloma patients efficiently internalize different classes of myeloma protein, Exp Hematol, 2001, 29 (1), 85-92.
Kelly, K. A. Walker, J. C. Jameel, S. H. Gray, H. L. Rank, R. G., Differential regulation of CD4 lymphocyte recruitment between the upper and lower regions of the genital tract during Chlamydia trachomatis infection, Infect Immun, 2000, 68 (3), 1519-28.
Hawkins R.H., R.G. Rank and K.A. Kelly, Expression of the mucosal homing receptor alpha-4/ beta-7 is associated with enhanced migration to the chlamydial infected murine genital mucosa in vivo, Infection & Immunity, 2000, 68, 5587-5594.
Williams, DM Grubbs, BG Darville, T Kelly, K Rank, RG, A role for interleukin-6 in host defense against murine Chlamydia trachomatis infection, Infection and immunity. , 1998, 66 (9), 4564-7.
Ojcius D.M., Y. Bravo, J.M. Kanellopoulos, R.A. Hawkins, K.A. Kelly, R.G. Rank and A. Daultry-Varsat, Intracellular processing and presentation of chlamydial-derived antigens by dendritic cells, Journal of Immunology, 1998, 160, 1297-1303.
Kelly, KA Rank, RG, Identification of homing receptors that mediate the recruitment of CD4 T cells to the genital tract following intravaginal infection with Chlamydia trachomatis, Infection and immunity. , 1997, 65 (12), 5198-208.
Williams, DM Grubbs, BG Pack, E Kelly, K Rank, RG, Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis, Infection and immunity. , 1997, 65 (7), 2876-82.
Kelly K.A., Modulation of leukocyte-endothelial interactions by infectious agents, Bull. Inst. Pasteur, 1997, 95, 147-159.
Williams, DM Grubbs, BG Kelly, K Pack, E Rank, RG, Role of gamma-delta T cells in murine Chlamydia trachomatis infection, Infection and immunity. , 1996, 64 (9), 3916-9.
Kelly K.A., E. Robinson, R.G. Rank, Initial route of antigen administration alters the T cell cytokine profile produced in response to the mouse pneumonitits biovar of Chlamydia trachomatis, Infection & Immunity, 1996, 64, 4976-83.