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Ren Sun, Ph.D.

   
Professor, Molecular & Medical Pharmacology, Bioengineering
Senior Associate Dean of Graduate Studies, David Geffen School of Medicine at UCLA
Associate Vice Provost, International Institute

Education:
Degrees:
Ph.D., Yale University, 1993
Fellowships:
1993 - 1997 Yale University, Post-Doctoral Fellow: Virology

Academic Experience:
Fellowships:
2011 - Zhejiang, Westlake Friendship Award

Honors and Awards:
2011 Westlake Friendship Award
2002 - Burroughs Welcome Fund, Investigator on Pathogenisis of Infectious Disease
1999 Stop Cancer Career Development Award, Career Development Award
1998 Rogers Scholar Award
1994 - Swebilius Cancer Research Award

Academic Experience:
Academic Experience:
1993 - 1997 Yale University, Genetics/Virology

Contact Information:
Work Email Address: rsun@mednet.ucla.edu
Mailing Address: Mail Code: 951735
Los Angeles, CA 90095
UNITED STATES
Work Address: UCLA Mol & Medl Pharmacol
BOX 959517, 10-155A Factor
Los Angeles, CA 90095
UNITED STATES
Work Address: Laboratory
Factor
Los Angeles, CA 90095
UNITED STATES
Home Page: http://faculty.pharmacology.ucla.edu/institution/personnel?personnel_id=45881
Home Page: http://labs.pharmacology.ucla.edu/sunlab/
Laboratory: https://scholar.google.com/citations?hl=en&user=xQG2cakAAAAJ&view_op=list_works&sortby=pubdate
Work Phone Number: (310) 794-5557 Phone
Research Interests:

My laboratory takes systems biology approaches to characterize the virus replication capacity, in the presence of specific immune response, drug selection, and host-viral interactions, at the genomic scale. We integrate multi-disciplinary methods, including viral genetics, molecular and cellular biology, genomics, structural biology, microfluidics, informatics and mathematic modeling. We currently study the following viruses: Kaposi sarcoma-associate herpesvirus (KSHV), murine herpesvirus-68 (MHV-68), influenza virus, Zika virus and human immune-deficient virus (HIV). We have recently developed a method that will enable us to generate a functional genetic map of an entire viral genome at single nucleotide resolution. These studies will generate functional genomic maps that lay the foundation for comprehensively defining virus-host interactions, and accelerate rational vaccine design and drug development. One focus of my lab is to generate and utilize the high-resolution viral genomic information to precisely design vaccines. Traditional genetics focuses on the linkage of one mutation and one phenotype. Our approach is an innovative genetic platform that enables us to scan the entire HIV-1/influenza virus genome to identify sequences essential for viral replication at particular selection conditions such as interferons and cytotoxic T cells, etc. The identification of functional sequences in the entire viral genome at a high resolution establishes a solid foundation for rational vaccine design and enable precision-engineering. We have demonstrated with herpesvirus and influenza virus in mice-infection models, the viruses become more immunogenic than the wild type, but severely attenuated in vivo when we systematically remove the immune-evasion functions from the virus genome. Thereby, it can be a general rational approach to develop therapeutic or preventive vaccine for many other pathogens. Furthermore, we can use this approach to engineer viruses (cancer vaccines) to preferentially replicate in cancer cells and strongly stimulate immune responses against tumor antigens.





Selected Publications:

Qi Hangfei, Chu Virginia, Wu Nicholas C, Chen Zugen, Truong Shawna, Brar Gurpreet, Su Sheng-Yao, Du Yushen, Arumugaswami Vaithilingaraja, Olson C Anders, Chen Shu-Hua, Lin Chung-Yen, Wu Ting-Ting, Sun Ren, Systematic identification of anti-interferon function on hepatitis C virus genome reveals p7 as an immune evasion protein, Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (8), 2018-2023.
Dai Xinghong, Li Zhihai, Lai Mason, Shu Sara, Du Yushen, Zhou Z Hong, Sun Ren, In situ structures of the genome and genome-delivery apparatus in a single-stranded RNA virus, Nature, 2017, 541 (7635), 112-116.
Gong Danyang, Kim Yong Hoon, Xiao Yuchen, Du Yushen, Xie Yafang, Lee Kevin K, Feng Jun, Farhat Nisar, Zhao Dawei, Shu Sara, Dai Xinghong, Chanda Sumit K, Rana Tariq M, Krogan Nevan J, Sun Ren, Wu Ting-Ting, A Herpesvirus Protein Selectively Inhibits Cellular mRNA Nuclear Export, Cell host & microbe, 2016, 20 (5), 642-653.
Du Yushen, Wu Nicholas C, Jiang Lin, Zhang Tianhao, Gong Danyang, Shu Sara, Wu Ting-Ting, Sun Ren, Annotating Protein Functional Residues by Coupling High-Throughput Fitness Profile and Homologous-Structure Analysis, mBio, 2016, 7 (6), 642-653.
Wu Nicholas C, Dai Lei, Olson C Anders, Lloyd-Smith James O, Sun Ren, Adaptation in protein fitness landscapes is facilitated by indirect paths, eLife, 2016, 5 (17), 19895-904.
Zhang Tian-Hao, Wu Nicholas C, Sun Ren, A benchmark study on error-correction by read-pairing and tag-clustering in amplicon-based deep sequencing, BMC genomics, 2016, 17 (17), 108.
Wu Nicholas C, Olson C Anders, Sun Ren, High-throughput identification of protein mutant stability computed from a double mutant fitness landscape, Protein science : a publication of the Protein Society, 2016, 25 (2), 530-9.
Wu Nicholas C, Du Yushen, Le Shuai, Young Arthur P, Zhang Tian-Hao, Wang Yuanyuan, Zhou Jian, Yoshizawa Janice M, Dong Ling, Li Xinmin, Wu Ting-Ting, Sun Ren, Coupling high-throughput genetics with phylogenetic information reveals an epistatic interaction on the influenza A virus M segment, BMC genomics, 2016, 17 (2), 46.
Feng Jiaying, Gong Danyang, Fu Xudong, Wu Ting-ting, Wang Jane, Chang Jennifer, Zhou Jingting, Lu Gang, Wang Yibin, Sun Ren, M1 of Murine Gamma-Herpesvirus 68 Induces Endoplasmic Reticulum Chaperone Production, Scientific reports, 2015, 5 (7), 17228.
Qi Hangfei, Wu Nicholas C, Du Yushen, Wu Ting-Ting, Sun Ren, High-resolution genetic profile of viral genomes: why it matters, Current opinion in virology, 2015, 14 (2), 62-70.
Wu Nicholas C, Olson C Anders, Du Yushen, Le Shuai, Tran Kevin, Remenyi Roland, Gong Danyang, Al-Mawsawi Laith Q, Qi Hangfei, Wu Ting-Ting, Sun Ren, Functional Constraint Profiling of a Viral Protein Reveals Discordance of Evolutionary Conservation and Functionality, PLoS genetics, 2015, 11 (7), e1005310.
Dai Xinghong, Gong Danyang, Xiao Yuchen, Wu Ting-Ting, Sun Ren, Zhou Z Hong, CryoEM and mutagenesis reveal that the smallest capsid protein cements and stabilizes Kaposi's sarcoma-associated herpesvirus capsid, Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (7), E649-56.
Al-Mawsawi Laith Q, Wu Nicholas C, Olson C Anders, Shi Vivian Cai, Qi Hangfei, Zheng Xiaojuan, Wu Ting-Ting, Sun Ren, High-throughput profiling of point mutations across the HIV-1 genome, Retrovirology, 2014, 11 (2), 124.
Olson C Anders, Wu Nicholas C, Sun Ren, A comprehensive biophysical description of pairwise epistasis throughout an entire protein domain, Current biology : CB, 2014, 24 (22), 2643-51.
Dai Xinghong, Gong Danyang, Wu Ting-Ting, Sun Ren, Zhou Z Hong, Organization of capsid-associated tegument components in Kaposi's sarcoma-associated herpesvirus, Journal of virology, 2014, 88 (21), 12694-702.
Gong Danyang, Wu Nicholas C, Xie Yafang, Feng Jun, Tong Leming, Brulois Kevin F, Luan Harding, Du Yushen, Jung Jae U, Wang Cun-yu, Kang Mo Kwan, Park No-Hee, Sun Ren, Wu Ting-Ting, Kaposi's sarcoma-associated herpesvirus ORF18 and ORF30 are essential for late gene expression during lytic replication, Journal of virology, 2014, 88 (19), 11369-82.
Remenyi Roland, Qi Hangfei, Su Sheng-Yao, Chen Zugen, Wu Nicholas C, Arumugaswami Vaithilingaraja, Truong Shawna, Chu Virginia, Stokelman Tamar, Lo Hung-Hao, Olson C Anders, Wu Ting-Ting, Chen Shu-Hwa, Lin Chung-Yen, Sun Ren, A comprehensive functional map of the hepatitis C virus genome provides a resource for probing viral proteins, mBio, 2014, 5 (5), e01469-14.
Feng Jun, De Jesus Paul D, Su Victoria, Han Stephanie, Gong Danyang, Wu Nicholas C, Tian Yuan, Li Xudong, Wu Ting-Ting, Chanda Sumit K, Sun Ren, RIOK3 Is an Adaptor Protein Required for IRF3-Mediated Antiviral Type I Interferon Production, Journal of virology, 2014, 88 (14), 7987-97.
Mangul Serghei, Wu Nicholas C, Mancuso Nicholas, Zelikovsky Alex, Sun Ren, Eskin Eleazar, Accurate viral population assembly from ultra-deep sequencing data, Bioinformatics (Oxford, England), 2014, 30 (12), i329-i337.
Ning Shaoyang, Xu Hongquan, Al-Shyoukh Ibrahim, Feng Jiaying, Sun Ren, An application of a Hill-based response surface model for a drug combination experiment on lung cancer, Statistics in medicine, 2014.
Al-Mawsawi Laith Q, Wu Nicholas C, De La Cruz Justin, Shi Vivian Cai, Wu Ting-Ting, Daar Eric S, Lewis Martha J, Yang Otto O, Sun Ren, HIV-1 gag Genetic Variation in a Single Acutely Infected Participant Defined by High-Resolution Deep Sequencing, AIDS research and human retroviruses, 2014.
Wu Nicholas C, Young Arthur P, Al-Mawsawi Laith Q, Olson C Anders, Feng Jun, Qi Hangfei, Luan Harding H, Li Xinmin, Wu Ting-Ting, Sun Ren, High-throughput identification of loss-of-function mutations for anti-interferon activity in influenza A virus NS segment, Journal of virology, 2014, 88 (14).
Wu Nicholas C, Young Arthur P, Al-Mawsawi Laith Q, Olson C Anders, Feng Jun, Qi Hangfei, Chen Shu-Hwa, Lu I-Hsuan, Lin Chung-Yen, Chin Robert G, Luan Harding H, Nguyen Nguyen, Nelson Stanley F, Li Xinmin, Wu Ting-Ting, Sun Ren, High-throughput profiling of influenza A virus hemagglutinin gene at single-nucleotide resolution, Scientific reports, 2014, 4, 4942.
Qi Hangfei, Olson C Anders, Wu Nicholas C, Ke Ruian, Loverdo Claude, Chu Virginia, Truong Shawna, Remenyi Roland, Chen Zugen, Du Yushen, Su Sheng-Yao, Al-Mawsawi Laith Q, Wu Ting-Ting, Chen Shu-Hua, Lin Chung-Yen, Zhong Weidong, Lloyd-Smith James O, Sun Ren, A quantitative high-resolution genetic profile rapidly identifies sequence determinants of hepatitis C viral fitness and drug sensitivity, PLoS pathogens, 2014, 10 (4), e1004064.
Wu Nicholas C, De La Cruz Justin, Al-Mawsawi Laith Q, Olson C Anders, Qi Hangfei, Luan Harding H, Nguyen Nguyen, Du Yushen, Le Shuai, Wu Ting-Ting, Li Xinmin, Lewis Martha J, Yang Otto O, Sun Ren, HIV-1 quasispecies delineation by tag linkage deep sequencing, PloS one, 2014, 9 (5), e97505.
Ke Ruian, Loverdo Claude, Qi Hangfei, Olson C Anders, Wu Nicholas C, Sun Ren, Lloyd-Smith James O, Modelling clinical data shows active tissue concentration of daclatasvir is 10-fold lower than its plasma concentration, The Journal of antimicrobial chemotherapy, 2014, 69 (3), 724-7.
Wong-Ho Elaine, Wu Ting-Ting, Davis Zoe H, Zhang Bingqing, Huang Jian, Gong Hao, Deng Hongyu, Liu Fenyong, Glaunsinger Britt, Sun Ren, Unconventional sequence requirement for viral late gene core promoters of murine gammaherpesvirus 68, Journal of virology, 2014, 88 (6), 3411-22.
Dolan Patrick T, Zhang Chaoying, Khadka Sudip, Arumugaswami Vaithilingaraja, Vangeloff Abbey D, Heaton Nicholas S, Sahasrabudhe Sudhir, Randall Glenn, Sun Ren, LaCount Douglas J, Identification and comparative analysis of hepatitis C virus-host cell protein interactions, Molecular bioSystems, 2013, 9 (12), 3199-209.
Wei Qingshan, Qi Hangfei, Luo Wei, Tseng Derek, Ki So Jung, Wan Zhe, Göröcs Zoltán, Bentolila Laurent A, Wu Ting-Ting, Sun Ren, Ozcan Aydogan, Fluorescent imaging of single nanoparticles and viruses on a smart phone, ACS nano, 2013, 7 (10), 9147-55.
Wei Qingshan, McLeod Euan, Qi Hangfei, Wan Zhe, Sun Ren, Ozcan Aydogan, On-Chip Cytometry using Plasmonic Nanoparticle Enhanced Lensfree Holography, Scientific reports, 2013, 3, 1699.
Wu Nicholas C, Young Arthur P, Dandekar Sugandha, Wijersuriya Hemani, Al-Mawsawi Laith Q, Wu Ting-Ting, Sun Ren, Systematic identification of H274Y compensatory mutations in influenza A virus neuraminidase by high-throughput screening, Journal of virology, 2013, 87 (2), 1193-9.
Olson C Anders, Nie Jeff, Diep Jonathan, Al-Shyoukh Ibrahim, Takahashi Terry T, Al-Mawsawi Laith Q, Bolin Jennifer M, Elwell Angela L, Swanson Scott, Stewart Ron, Thomson James A, Soh H Tom, Roberts Richard W, Sun Ren, Single-round, multiplexed antibody mimetic design through mRNA display, Angewandte Chemie (International ed. in English), 2012, 51 (50), 12449-53.
Stevens Hannah C, Cham Kevin S-W, Hughes David J, Sun Ren, Sample Jeffery T, Bubb Vivien J, Stewart James P, Quinn John P, CTCF and Sp1 interact with the Murine gammaherpesvirus 68 internal repeat elements, Virus genes, 2012, 45 (2), 265-73.
Wu Ting-Ting, Qian Jing, Ang Jian, Sun Ren, Vaccine prospect of Kaposi sarcoma-associated herpesvirus, Current opinion in virology, 2012, 2 (4), 482-8.
Li Xudong, Chen Shijia, Sun Ren, Cdk1 inhibition induces mutually inhibitory apoptosis and reactivation of Kaposi's sarcoma-associated herpesvirus, Journal of virology, 2012, 86 (12), 6668-76.
Weng Ding, Qi Hangfei, Wu Ting-Ting, Yan Ming, Sun Ren, Lu Yunfeng, Visible light powered self-disinfecting coatings for influenza viruses, Nanoscale, 2012, 4 (9), 2870-4.
Wang Lili, Guo Haitao, Reyes Nichole, Lee Shaoying, Bortz Eric, Guo Fengli, Sun Ren, Tong Liang, Deng Hongyu, Distinct Domains in ORF52 Tegument Protein Mediate Essential Functions in Murine Gammaherpesvirus 68 Virion Tegumentation and Secondary Envelopment, Journal of virology, 2012, 86 (3), 1348-57.
Kang Hye-Ri, Cho Hye-Jeong, Kim Sungbum, Song In Ho, Lee Tae Sup, Hwang Seungmin, Sun Ren, Song Moon Jung, Persistent infection of a gammaherpesvirus in the central nervous system, Virology, 2012, 423 (1), 23-9.
Noh Cheol-Woo, Cho Hye-Jeong, Kang Hye-Ri, Jin Hyun Yong, Lee Shaoying, Deng Hongyu, Wu Ting-Ting, Arumugaswami Vaithilingaraja, Sun Ren, Song Moon Jung, The Virion-Associated Open Reading Frame 49 of Murine Gammaherpesvirus 68 Promotes Viral Replication both In Vitro and In Vivo as a Derepressor of RTA, Journal of virology, 2012, 86 (2), 1109-18.
Tyynismaa Henna, Sun Ren, Ahola-Erkkilä Sofia, Almusa Henrikki, Pöyhönen Rosanna, Korpela Mari, Honkaniemi Jari, Isohanni Pirjo, Paetau Anders, Wang Liya, Suomalainen Anu, Thymidine kinase 2 mutations in autosomal recessive progressive external ophthalmoplegia with multiple mitochondrial DNA deletions, Human molecular genetics, 2012, 21 (1), 66-75.
Freeman Michael L, Burkum Claire E, Woodland David L, Sun Ren, Wu Ting-Ting, Blackman Marcia A, Importance of Antibody in Virus Infection and Vaccine-Mediated Protection by a Latency-Deficient Recombinant Murine γ-Herpesvirus-68, Journal of immunology (Baltimore, Md. : 1950), 2011, 86 (2).
Lee Shaoying, Salwinski Lukasz, Zhang Chaoying, Chu Derrick, Sampankanpanich Claire, Reyes Nichole A, Vangeloff Abbey, Xing Fangfang, Li Xudong, Wu Ting-Ting, Sahasrabudhe Sudhir, Deng Hongyu, Lacount Douglas J, Sun Ren, An integrated approach to elucidate the intra-viral and viral-cellular protein interaction networks of a gamma-herpesvirus, PLoS pathogens, 2011, 7 (10), e1002297.
Liu Yanan, Tian Xiaoli, Leitner Wolfgang W, Aldridge Michael E, Zheng Junying, Yu Zhiya, Restifo Nicholas P, Weiss Richard, Scheiblhofer Sandra, Xie Chong, Sun Ren, Cheng Genhong, Zeng Gang, Polymeric structure and host Toll-like receptor 4 dictate immunogenicity of NY-ESO-1 antigen in vivo, The Journal of biological chemistry, 2011, 286 (43), 37077-84.
Leang Ronika Sitapara, Wu Ting-Ting, Hwang Seungmin, Liang Lidia T, Tong Leming, Truong Jennifer T, Sun Ren, The Anti-interferon Activity of Conserved Viral dUTPase ORF54 is Essential for an Effective MHV-68 Infection, PLoS pathogens, 2011, 7 (10), e1002292.
Olson C Anders, Adams Jonathan D, Takahashi Terry T, Qi Hangfei, Howell Shannon M, Wu Ting-Ting, Roberts Richard W, Sun Ren, Soh H Tom, Rapid mRNA-Display Selection of an IL-6 Inhibitor Using Continuous-Flow Magnetic Separation, Angewandte Chemie (International ed. in English), 2011, 7 (10).
Wu Ting-Ting, Liao Hsiang-I, Tong Leming, Leang Ronika Sitapara, Smith Greg, Sun Ren, Construction and characterization of an infectious murine gammaherpesivrus-68 bacterial artificial chromosome, Journal of biomedicine & biotechnology, 2011, 2011 (6), 926258.
Ferguson B Scott, Buchsbaum Steven F, Wu Ting-Ting, Hsieh Kuangwen, Xiao Yi, Sun Ren, Soh H Tom, Genetic analysis of H1N1 influenza virus from throat swab samples in a microfluidic system for point-of-care diagnostics, Journal of the American Chemical Society, 2011, 133 (23), 9129-35.
Al-Shyoukh Ibrahim, Yu Fuqu, Feng Jiaying, Yan Karen, Dubinett Steven, Ho Chih-Ming, Shamma Jeff S, Sun Ren, Systematic quantitative characterization of cellular responses induced by multiple signals, BMC systems biology, 2011, 5 (6), 88.
Yu Fuqu, Al-Shyoukh Ibrahim, Feng Jiaying, Li Xudong, Liao Chia Wei, Ho Chih-Ming, Shamma Jeff S, Sun Ren, Control of Kaposi's sarcoma-associated herpesvirus reactivation induced by multiple signals, PloS one, 2011, 6 (6), e20998.
Li Xudong, Feng Jiaying, Sun Ren, Oxidative stress induces reactivation of Kaposi's sarcoma-associated herpesvirus and death of primary effusion lymphoma cells, Journal of virology, 2011, 85 (2), 715-24.
Wu Ting-Ting, Blackman Marcia A, Sun Ren, Prospects of a novel vaccination strategy for human gamma-herpesviruses, Immunologic research, 2010, 48 (1-3), 122-46.
Ishikawa Fumiaki N, Curreli Marco, Olson C Anders, Liao Hsiang-I, Sun Ren, Roberts Richard W, Cote Richard J, Thompson Mark E, Zhou Chongwu, Importance of controlling nanotube density for highly sensitive and reliable biosensors functional in physiological conditions, ACS nano, 2010, 4 (11), 6914-22.
Lu Chih-Chung, Li Zhonghan, Chu Chia-Ying, Feng Jiaying, Feng Jun, Sun Ren, Rana Tariq M, MicroRNAs encoded by Kaposi's sarcoma-associated herpesvirus regulate viral life cycle, EMBO reports, 2010, 11 (10), 784-90.
Li Xudong, Chen Shijia, Feng Jun, Deng Hongyu, Sun Ren, Myc is required for the maintenance of Kaposi's sarcoma-associated herpesvirus latency, Journal of virology, 2010, 84 (17), 8945-8.
Brown Helen J, Peng Li, Harada Josephine N, Walker John R, Cole Steven, Lin Su-Fang, Zack Jerome A, Chanda Sumit K, Sun Ren, Gene expression and transcription factor profiling reveal inhibition of transcription factor cAMP-response element-binding protein by gamma-herpesvirus replication and transcription activator, The Journal of biological chemistry, 2010, 285 (33), 25139-53.
Dong Xiaonan, Feng Hao, Sun Qinmiao, Li Haiyan, Wu Ting-Ting, Sun Ren, Tibbetts Scott A, Chen Zhijian J, Feng Pinghui, Murine gamma-herpesvirus 68 hijacks MAVS and IKKbeta to initiate lytic replication, PLoS pathogens, 2010, 6 (7), e1001001.
Jia Qingmei, Freeman Michael L, Yager Eric J, McHardy Ian, Tong Leming, Martinez-Guzman DeeAnn, Rickabaugh Tammy, Hwang Seungmin, Blackman Marcia A, Sun Ren, Wu Ting-Ting, Induction of protective immunity against murine gammaherpesvirus 68 infection in the absence of viral latency, Journal of virology, 2010, 84 (5), 2453-65.
Freeman Michael L, Lanzer Kathleen G, Cookenham Tres, Peters Bjoern, Sidney John, Wu Ting-Ting, Sun Ren, Woodland David L, Sette Alessandro, Blackman Marcia A, Two kinetic patterns of epitope-specific CD8 T-cell responses following murine gammaherpesvirus 68 infection, Journal of virology, 2010, 84 (6), 2881-92.
Peng Li, Wu Ting-Ting, Tchieu Jason H, Feng Jun, Brown Helen J, Feng Jiaying, Li Xudong, Qi Jing, Deng Hongyu, Vivanco Igor, Mellinghoff Ingo K, Jamieson Christina, Sun Ren, Inhibition of the phosphatidylinositol 3-kinase-Akt pathway enhances gamma-2 herpesvirus lytic replication and facilitates reactivation from latency, The Journal of general virology, 2010, 91 (Pt 2), 463-9.
Li Xudong, Feng Jun, Chen Shijia, Peng Li, He Wei-Wu, Qi Jing, Deng Hongyu, Sun Ren, Tpl2/AP-1 enhances murine gammaherpesvirus 68 lytic replication, Journal of virology, 2010, 84 (4), 1881-90.
Peng Li, Ryazantsev Sergey, Sun Ren, Zhou Z Hong, Three-dimensional visualization of gammaherpesvirus life cycle in host cells by electron tomography, Structure (London, England : 1993), 2010, 18 (1), 47-58.
Gonzalez Oscar, Fontanes Vanessa, Raychaudhuri Santanu, Loo Rachel, Loo Joseph, Arumugaswami Vaithilingaraja, Sun Ren, Dasgupta Asim, French Samuel W, The heat shock protein inhibitor Quercetin attenuates hepatitis C virus production, Hepatology (Baltimore, Md.), 2009, 50 (6), 1756-64.
E Xiaofei, Hwang Seungmin, Oh Soohwan, Lee Jong-Soo, Jeong Joseph H, Gwack Yousang, Kowalik Timothy F, Sun Ren, Jung Jae U, Liang Chengyu, Viral Bcl-2-mediated evasion of autophagy aids chronic infection of gammaherpesvirus 68, PLoS pathogens, 2009, 5 (10), e1000609.
Chen Su, Palmer James F, Zhang Wei, Shao Jing, Li Si, Fan Liu-Yin, Sun Ren, Dong Yu-Chao, Cao Cheng-Xi, A simple preparative free-flow electrophoresis joined with gratis gravity: I. Gas cushion injector and self-balance collector instead of multiple channel pump, Electrophoresis, 2009, 30 (11), 1998-2007.
Liao Hsiang-I, Olson C Anders, Hwang Seungmin, Deng Hongyu, Wong Elaine, Baric Ralph S, Roberts Richard W, Sun Ren, mRNA display design of fibronectin-based intrabodies that detect and inhibit severe acute respiratory syndrome coronavirus nucleocapsid protein, The Journal of biological chemistry, 2009, 284 (26), 17512-20.
Gong Danyang, Qi Jing, Arumugaswami Vaithilingaraja, Sun Ren, Deng Hongyu, Identification and functional characterization of the left origin of lytic replication of murine gammaherpesvirus 68, Virology, 2009, 387 (2), 285-95.
Ishikawa Fumiaki N, Chang Hsiao-Kang, Curreli Marco, Liao Hsiang-I, Olson C Anders, Chen Po-Chiang, Zhang Rui, Roberts Richard W, Sun Ren, Cote Richard J, Thompson Mark E, Zhou Chongwu, Label-free, electrical detection of the SARS virus N-protein with nanowire biosensors utilizing antibody mimics as capture probes, ACS nano, 2009, 3 (5), 1219-24.
Di Bartolo Daniel L, Hyjek Elizabeth, Keller Shannon, Guasparri Ilaria, Deng Hongyu, Sun Ren, Chadburn Amy, Knowles Daniel M, Cesarman Ethel, Role of defective Oct-2 and OCA-B expression in immunoglobulin production and Kaposi's sarcoma-associated herpesvirus lytic reactivation in primary effusion lymphoma, Journal of virology, 2009, 83 (9), 4308-15.
Wu Ting-Ting, Park Tina, Kim Hana, Tran Thuy, Tong Leming, Martinez-Guzman DeeAnn, Reyes Nichole, Deng Hongyu, Sun Ren, ORF30 and ORF34 are essential for expression of late genes in murine gammaherpesvirus 68, Journal of virology, 2009, 83 (5), 2265-73.
Hwang Seungmin, Kim Kyeong Seon, Flano Emilio, Wu Ting-Ting, Tong Leming M, Park Ann N, Song Moon Jung, Sanchez David Jesse, O'Connell Ryan M, Cheng Genhong, Sun Ren, Conserved herpesviral kinase promotes viral persistence by inhibiting the IRF-3-mediated type I interferon response, Cell host & microbe, 2009, 5 (2), 166-78.
Arumugaswami Vaithilingaraja, Sitapara Ronika, Hwang Seungmin, Song Moon Jung, Ho Tuyet Ngoc, Su Nancy Qi, Sue Eric Y, Kanagavel Vidhya, Xing Fangfang, Zhang Xiaolin, Zhao Minglei, Deng Hongyu, Wu Ting-Ting, Kanagavel Sudhakar, Zhang LuLu, Dandekar Sugandha, Papp Jeanette, Sun Ren, High-resolution functional profiling of a gammaherpesvirus RTA locus in the context of the viral genome, Journal of virology, 2009, 83 (4), 1811-22.
Miyahira Andrea K, Shahangian Arash, Hwang Seungmin, Sun Ren, Cheng Genhong, TANK-binding kinase-1 plays an important role during in vitro and in vivo type I IFN responses to DNA virus infections, Journal of immunology, 2009, 182 (4), 2248-57.
Sun Chien-Pin, Usui Takane, Yu Fuqu, Al-Shyoukh Ibrahim, Shamma Jeff, Sun Ren, Ho Chih-Ming, Integrative systems control approach for reactivating Kaposi's sarcoma-associated herpesvirus (KSHV) with combinatory drugs, Integrative biology : quantitative biosciences from nano to macro, 2009, 1 (1), 123-30.
Cheng Lucy S, Hwang Seungmin, Huang Tzu-Hsuan, Sheu Ting-Chang, Sun Ren, Morrison Sherie L, Cheng Genhong, Shahangian Arash, Antibody-fused interferons as an effective approach to enhance target specificity and antiviral efficacy of type I interferons, Cell research, 2008, 18 (12), 1230-2.
Hwang Seungmin, Wu Ting-Ting, Tong Leming M, Kim Kyeong Seon, Martinez-Guzman DeeAnn, Colantonio Arnaud D, Uittenbogaart Christel H, Sun Ren, Persistent gammaherpesvirus replication and dynamic interaction with the host in vivo, Journal of virology, 2008, 82 (24), 12498-509.
Arumugaswami Vaithilingaraja, Remenyi Roland, Kanagavel Vidhya, Sue Eric Yiang, Ngoc Ho Tuyet, Liu Chang, Fontanes Vanessa, Dasgupta Asim, Sun Ren, High-resolution functional profiling of hepatitis C virus genome, PLoS pathogens, 2008, 4 (10), e1000182.
Wang Leyao, Shan Liang, Lo Kwok Wai, Yin Juan, Zhang Yuanyuan, Sun Ren, Zhong Jiang, Inhibition of nasopharyngeal carcinoma growth by RTA-expressing baculovirus vectors containing oriP, The Journal of Gene Medicine, 2008, 10 (10), 1124-33.
Song Changyong, Jiang Huaidong, Mancuso Adrian, Amirbekian Bagrat, Peng Li, Sun Ren, Shah Sanket S, Zhou Z Hong, Ishikawa Tetsuya, Miao Jianwei, Quantitative imaging of single, unstained viruses with coherent x rays, Physical review letters, 2008, 101 (15), 158101.
Lee Shaoying, Deng Hongyu, Yu Fuqu, Melega William P, Damoiseaux Robert, Bradley Kenneth A, Sun Ren, Regulation of Kaposi's sarcoma-associated herpesvirus reactivation by dopamine receptor-mediated signaling pathways, Journal of acquired immune deficiency syndromes (1999), 2008, 48 (5), 531-40.
Olson C Anders, Liao Hsiang-I, Sun Ren, Roberts Richard W, mRNA display selection of a high-affinity, modification-specific phospho-IkappaBalpha-binding fibronectin, ACS chemical biology, 2008, 3 (8), 480-5.
Yu Lei, Zhang Baohua, Szilvay Géza R, Sun Ren, Jänis Janne, Wang Zefang, Feng Shuren, Xu Haijin, Linder Markus B, Qiao Mingqiang, Protein HGFI from the edible mushroom Grifola frondosa is a novel 8 kDa class I hydrophobin that forms rodlets in compressed monolayers, Microbiology (Reading, England), 2008, 154 (Pt 6), 1677-85.
Wong Pak Kin, Yu Fuqu, Shahangian Arash, Cheng Genhong, Sun Ren, Ho Chih-Ming, Closed-loop control of cellular functions using combinatory drugs guided by a stochastic search algorithm, Proceedings of the National Academy of Sciences of the United States of America, 2008, 105 (13), 5105-10.
Sanchez David Jesse, Miranda Daniel, Arumugaswami Vaithilingaraja, Hwang Seungmin, Singer Adam E, Senaati Ashkon, Shahangian Arash, Song Moon Jung, Sun Ren, Cheng Genhong, A repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon, Journal of virology, 2008, 82 (5), 2208-17.
Dai Wei, Jia Qingmei, Bortz Eric, Shah Sanket, Liu Jun, Atanasov Ivo, Li Xudong, Taylor Kenneth A, Sun Ren, Zhou Z Hong, Unique structures in a tumor herpesvirus revealed by cryo-electron tomography and microscopy, Journal of structural biology, 2008, 161 (3), 428-38.
Cho Hye-Jeong, Yu Fuqu, Sun Ren, Lee Dongho, Song Moon Jung, Lytic induction of Kaposi's sarcoma-associated herpesvirus in primary effusion lymphoma cells with natural products identified by a cell-based fluorescence moderate-throughput screening, Archives of virology, 2008, 153 (8), 1517-25.
Pavlovic Elizabeth, Lai Rebecca Y, Wu Ting Ting, Ferguson Brian S, Sun Ren, Plaxco Kevin W, Soh H T, Microfluidic device architecture for electrochemical patterning and detection of multiple DNA sequences, Langmuir , 2008, 24 (3), 1102-7.
Feng Pinghui, Liang Chengyu, Shin Young C, Xiaofei E, Zhang Weijun, Gravel Robyn, Wu Ting-ting, Sun Ren, Usherwood Edward, Jung Jae U, A novel inhibitory mechanism of mitochondrion-dependent apoptosis by a herpesviral protein, PLoS pathogens, 2007, 3 (12), e174.
Kayhan Basak, Yager Eric J, Lanzer Kathleen, Cookenham Tres, Jia Qingmei, Wu Ting-Ting, Woodland David L, Sun Ren, Blackman Marcia A, A replication-deficient murine gamma-herpesvirus blocked in late viral gene expression can establish latency and elicit protective cellular immunity, Journal of immunology , 2007, 179 (12), 8392-402.
Sun Ren, Chwang Allen T, Interactions between two touching spherical particles in sedimentation, Physical review. E, Statistical, nonlinear, and soft matter physics, 2007, 76 (4 Pt 2), 046316.
Benach Jordi, Wang Lili, Chen Yang, Ho Chi Kent, Lee Shaoying, Seetharaman Jayaraman, Xiao Rong, Acton Thomas B, Montelione Gaetano T, Deng Hongyu, Sun Ren, Tong Liang, Structural and functional studies of the abundant tegument protein ORF52 from murine gammaherpesvirus 68, The Journal of biological chemistry, 2007, 282 (43), 31534-41.
Bortz Eric, Wang Lili, Jia Qingmei, Wu Ting-Ting, Whitelegge Julian P, Deng Hongyu, Zhou Z Hong, Sun Ren, Murine gammaherpesvirus 68 ORF52 encodes a tegument protein required for virion morphogenesis in the cytoplasm, Journal of virology, 2007, 81 (18), 10137-50.
Lee Sangmi, Cho Hye-Jeong, Park Jung-Jin, Kim Yong-Sun, Hwang Seungmin, Sun Ren, Song Moon Jung, The ORF49 protein of murine gammaherpesvirus 68 cooperates with RTA in regulating virus replication, Journal of virology, 2007, 81 (18), 9870-7.
Yu Fuqu, Feng Jiaying, Harada Josephine N, Chanda Sumit K, Kenney Shannon C, Sun Ren, B cell terminal differentiation factor XBP-1 induces reactivation of Kaposi's sarcoma-associated herpesvirus, FEBS letters, 2007, 581 (18), 3485-8.
Wong PK, Yu F, Sun R, Ho CM, Unraveling gene regulatory networks using an integrated microfluidic platform, IEEE, 2007.
Tarakanova Vera L, Leung-Pineda Van, Hwang Seungmin, Yang Chiao-Wen, Matatall Katie, Basson Mickael, Sun Ren, Piwnica-Worms Helen, Sleckman Barry P, Virgin Herbert W, Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication, Cell host & microbe, 2007, 1 (4), 275-86.
Wong Elaine, Wu Ting-Ting, Reyes Nichole, Deng Hongyu, Sun Ren, Murine gammaherpesvirus 68 open reading frame 24 is required for late gene expression after DNA replication, Journal of virology, 2007, 81 (12), 6761-4.
Yu Fuqu, Harada Josephine N, Brown Helen J, Deng Hongyu, Song Moon Jung, Wu Ting-Ting, Kato-Stankiewicz Juran, Nelson Christian G, Vieira Jeffrey, Tamanoi Fuyuhiko, Chanda Sumit K, Sun Ren, Systematic identification of cellular signals reactivating Kaposi sarcoma-associated herpesvirus, PLoS pathogens, 2007, 3 (3), e44.
Arumugaswami Vaithilingaraja, Wu Ting-Ting, Martinez-Guzman DeeAnn, Jia Qingmei, Deng Hongyu, Reyes Nichole, Sun Ren, ORF18 is a transfactor that is essential for late gene transcription of a gammaherpesvirus, Journal of virology, 2006, 80 (19), 9730-40.
Deng H, Liang Y, Sun R, Regulation of HSHV lytic replication, Current Topics in Microbiology and Immunology, 2006, 312, 157-183.
Bowser Brian S, Morris Stephanie, Song Moon Jung, Sun Ren, Damania Blossom, Characterization of Kaposi's sarcoma-associated herpesvirus (KSHV) K1 promoter activation by Rta, Virology, 2006, 348 (2), 309-27.
Chang Margaret, Brown Helen J, Collado-Hidalgo Alicia, Arevalo Jesusa M, Galic Zoran, Symensma Tonia L, Tanaka Lena, Deng Hongyu, Zack Jerome A, Sun Ren, Cole Steve W, beta-Adrenoreceptors reactivate Kaposi's sarcoma-associated herpesvirus lytic replication via PKA-dependent control of viral RTA, Journal of virology, 2005, 79 (21), 13538-47.
Luz JG, Yu M, Su Y, Wu Z, Zhou Z, Sun R, Wilson IA., Crystal structure of viral macrophage inflammatory protein I encoded by Kaposi's sarcoma-associated herpesvirus at 1.7A, Journal of Molecular Biology, 2005, 352 (5), 1019-28.
Chang M, Brown HJ, Collado-Hidalgo A, Arevalo JM, Galic Z, Symensma TL, Tanaka L, Deng H, Zack JA, Sun R, Cole SW, Beta-Adrenoreceptors reactivate Kaposi's sarcoma-associated herpesvirus lytic replication via PKA-dependent control of viral RTA, J Virol, 2005, 79 (21), 13538-47.
Flaño Emilio, Jia Qingmei, Moore John, Woodland David L, Sun Ren, Blackman Marcia A, Early establishment of gamma-herpesvirus latency: implications for immune control, Journal of immunology (Baltimore, Md. : 1950), 2005, 174 (8), 4972-8.
Jia Qingmei, Chernishof Vasili, Bortz Eric, Mchardy Ian, Wu Ting-Ting, Liao Hsiang-I, Sun Ren, Murine gammaherpesvirus 68 open reading frame 45 plays an essential role during the immediate-early phase of viral replication, Journal of virology, 2005, 79 (8), 5129-41.
Song Moon Jung, Hwang Seungmin, Wong Wendy H, Wu Ting-Ting, Lee Sangmi, Liao Hsiang-I, Sun Ren, Identification of viral genes essential for replication of murine gamma-herpesvirus 68 using signature-tagged mutagenesis, Proceedings of the National Academy of Sciences of the United States of America, 2005, 102 (10), 3805-10.
Rickabaugh Tammy M, Brown Helen J, Wu Ting-Ting, Song Moon Jung, Hwang Seungmin, Deng Hongyu, Mitsouras Katherine, Sun Ren, Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 RTA reactivates murine gammaherpesvirus 68 from latency, Journal of virology, 2005, 79 (5), 3217-22.
Brown Helen J, McBride William H, Zack Jerome A, Sun Ren, Prostratin and bortezomib are novel inducers of latent Kaposi's sarcoma-associated herpesvirus, Antiviral therapy, 2005, 10 (6), 745-51.
Liu Rui-min, Wang Xue-jun, Tao Shu, Shen Wei-ran, Qin Bao-ping, Sun Ren, Zhang Wen-Ju, [Multi-scale spatial relations of PAHs and soil properties in Tianjin area], Huan jing ke xue= Huanjing kexue / [bian ji, Zhongguo ke xue yuan huan jing ke xue wei yuan hui "Huan jing ke xue" bian ji wei yuan hui.], 2005, 26 (1), 141-4.
Song Moon Jung, Hwang Seungmin, Wong Wendy, Round June, Martinez-Guzman Deeann, Turpaz Yaron, Liang Jie, Wong Ben, Johnson Reid C, Carey Michael, Sun Ren, The DNA architectural protein HMGB1 facilitates RTA-mediated viral gene expression in gamma-2 herpesviruses, Journal of virology, 2004, 78 (23), 12940-50.
Rickabaugh Tammy M, Brown Helen J, Martinez-Guzman DeeAnn, Wu Ting-Ting, Tong Leming, Yu Fuqu, Cole Steven, Sun Ren, Generation of a latency-deficient gammaherpesvirus that is protective against secondary infection, Journal of virology, 2004, 78 (17), 9215-23.
Deng Hongyu, Chu Julia T, Park No-Hee, Sun Ren, Identification of cis sequences required for lytic DNA replication and packaging of murine gammaherpesvirus 68, Journal of virology, 2004, 78 (17), 9123-31.
Wu Shui-ping, Zuo Qian, Lan Tian, Deng Hui-wen, Li Ben-gang, Xu Fu-liu, Shen Wei-ran, Qin Bao-ping, Sun Ren, Tao Shu, [PAHs in airborne particles from Tianjin in winter season], Huan jing ke xue= Huanjing kexue / [bian ji, Zhongguo ke xue yuan huan jing ke xue wei yuan hui "Huan jing ke xue" bian ji wei yuan hui.], 2004, 25 (4), 13-7.
Hongyu Deng, Julia T. Chu, No-Hee Park, and Ren Sun., Functional Identification of an Original Lytic Replication and the Cleavage/Packaging Signal of Murine Gamaherpesvirus-68, Journal of Virology, 2004, 78 (17), 9123-9131.
Jia Qingmei, Wu Ting-Ting, Liao Hsiang-I, Chernishof Vasili, Sun Ren, Murine gammaherpesvirus 68 open reading frame 31 is required for viral replication, Journal of virology, 2004, 78 (12), 6610-20.
Symensma Tonia L, Martinez-Guzman DeeAnn, Jia Qingmei, Bortz Eric, Wu Ting-Ting, Rudra-Ganguly Nandini, Cole Steve, Herschman Harvey, Sun Ren, COX-2 induction during murine gammaherpesvirus 68 infection leads to enhancement of viral gene expression, Journal of virology, 2003, 77 (23), 12753-63.
Bortz Eric, Whitelegge Julian P, Jia Qingmei, Zhou Z Hong, Stewart James P, Wu Ting-Ting, Sun Ren, Identification of proteins associated with murine gammaherpesvirus 68 virions, Journal of virology, 2003, 77 (24), 13425-32.
Martinez-Guzman DeeAnn, Rickabaugh Tammy, Wu Ting-Ting, Brown Helen, Cole Steven, Song Moon Jung, Tong Leming, Sun Ren, Transcription program of murine gammaherpesvirus 68, Journal of virology, 2003, 77 (19), 10488-503.
Song Moon Jung, Deng Hongyu, Sun Ren, Comparative study of regulation of RTA-responsive genes in Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8, Journal of virology, 2003, 77 (17), 9451-62.
Brown Helen J, Song Moon Jung, Deng Hongyu, Wu Ting-Ting, Cheng Genhong, Sun Ren, NF-kappaB inhibits gammaherpesvirus lytic replication, Journal of virology, 2003, 77 (15), 8532-40.
An Jiabin, Sun Yiping, Sun Ren, Rettig Matthew B, Kaposi's sarcoma-associated herpesvirus encoded vFLIP induces cellular IL-6 expression: the role of the NF-kappaB and JNK/AP1 pathways, Oncogene, 2003, 22 (22), 3371-85.
Jia Qingmei, Sun Ren, Inhibition of gammaherpesvirus replication by RNA interference, Journal of virology, 2003, 77 (5), 3301-6.
Doyle Sean, Vaidya Sagar, O'Connell Ryan, Dadgostar Hajir, Dempsey Paul, Wu Ting, Rao Govinda, Sun Ren, Haberland Margaret, Modlin Robert, Cheng Genhong, IRF3 mediates a TLR3/TLR4-specific antiviral gene program, Immunity, 2002, 17 (3), 251-63.
Deng Hongyu, Chu Julia T, Rettig Matthew B, Martinez-Maza Otoniel, Sun Ren, Rta of the human herpesvirus 8/Kaposi sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression, Blood, 2002, 100 (5), 1919-21.
Deng Hongyu, Song Moon Jung, Chu Julia T, Sun Ren, Transcriptional regulation of the interleukin-6 gene of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus), Journal of virology, 2002, 76 (16), 8252-64.
Varthakavi Vasundhara, Smith Rita M, Deng Hongyu, Sun Ren, Spearman Paul, Human immunodeficiency virus type-1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus through induction of KSHV Rta, Virology, 2002, 297 (2), 270-80.
Song Moon Jung, Li Xudong, Brown Helen J, Sun Ren, Characterization of interactions between RTA and the promoter of polyadenylated nuclear RNA in Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8, Journal of virology, 2002, 76 (10), 5000-13.
Wu, T. T. Tong, L. Rickabaugh, T. Speck, S. Sun, R., Function of Rta is essential for lytic replication of murine gammaherpesvirus 68, J Virol, 2001, 75 (19), 9262-73.
Song, M. J. Brown, H. J. Wu, T. T. Sun, R. , Transcription activation of polyadenylated nuclear rna by rta in human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus, J Virol, 2001, 75 (7), 3129-40.
Chen, Y. Sun, R. Guan, T. Zhang, H. , [The Raman spectra study on crystal-octadecyl hydrogen succinate crystal], Guang Pu Xue Yu Guang Pu Fen Xi, 2001, 21 (2), 202-3.
Deng, H. Young, A. Sun, R. , Auto-activation of the rta gene of human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus, J Gen Virol, 2000, 81 (Pt 12), 3043-8.