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Faculty DataBase - FDB5

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Juli Feigon, Ph.D.

   
Lab Director, Feigon Lab
Professor, Chemistry and Biochemistry, Biochemistry, Molecular Biology
Member, Biochemistry, Biophysics & Structural Biology GPB Home Area, California NanoSystems Institute, Molecular Biology Institute
Staff, NMR Core (DOE), Nuclear Magnetic Resonance (NMR) Core Facility (DOE)
Researcher, Biochemistry, Biophysics and Structural Biology, Development and Gene Regulation

Education:
Degrees:
Ph.D., University of California, San Diego
M.S., University of California, San Diego
B.A., Occidental College

Academic Experience:
Fellowships:
1975 Phi Beta Kappa
1982 Damon Runyon-Walter Winchell Cancer Fund Postdoctoral Fellowship
1984 National Research Service Award, National Institute of General Medical Sciences, National Institutes of Health
1985 Dupont Young Faculty Award
1989 Presidential Young Investigator, National Science Foundation
1990 Camille and Henry Dreyfus Teacher/Scholar Award
1992 Glenn T. Seaborg Research Award
1993 Herbert Newby McCoy Award
2002 Fellow of the American Association for the Advancement of Science (AAAS)
2008 Council Member, International Society of Magnetic Resonance
2009 Member, National Academy of Sciences
Academic Experience:
Massachusetts Institute of Technology

Contact Information:
Work Email Address: feigon@mbi.ucla.edu
Laboratory Address: Mol Sci Bldg 1429
Laboratory Address: Paul Boyer Hall 270
Mailing Address: 607 Charles Young Dr. East
P.O. Box 951569
Los Angeles, CA 90095
UNITED STATES
Work Address: Paul Boyer Hall 241
Laboratory: http://www.biochemistry.ucla.edu/biochem/Faculty/Feigon/
Fax Number: (310) 825-0982
Work Phone Number: 1 (310) 206-6922 Office
Lab Number: 1 (310) 825-9232 Lab
1 (310) 206-3493 Lab

Selected Publications:

Cash Darian D, Cohen-Zontag Osnat, Kim Nak-Kyoon, Shefer Kinneret, Brown Yogev, Ulyanov Nikolai B, Tzfati Yehuda, Feigon Juli, Pyrimidine motif triple helix in the Kluyveromyces lactis telomerase RNA pseudoknot is essential for function in vivo, Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (27), 10970-5.
Jiang Jiansen, Miracco Edward J, Hong Kyungah, Eckert Barbara, Chan Henry, Cash Darian D, Min Bosun, Zhou Z Hong, Collins Kathleen, Feigon Juli, The architecture of Tetrahymena telomerase holoenzyme, Nature, 2013, 496 (7444), 187-92.
Hartman Elon, Wang Zhonghua, Zhang Qi, Roy Kevin, Chanfreau Guillaume, Feigon Juli, Intrinsic dynamics of an extended hydrophobic core in the S. cerevisiae RNase III dsRBD contributes to recognition of specific RNA binding sites, Journal of molecular biology, 2013, 425 (3), 546-62.
Singh Mahavir, Choi Charles P, Feigon Juli, xRRM: A new class of RRM found in the telomerase La family protein p65, RNA biology, 2013, 10 (3).
Kang Mijeong, Heuberger Ben, Chaput John C, Switzer Christopher, Feigon Juli, Solution structure of a parallel-stranded oligoisoguanine DNA pentaplex formed by d(T(iG)4 T) in the presence of Cs+ ions, Angewandte Chemie (International ed. in English), 2012, 51 (32), 7952-5.
Singh Mahavir, Wang Zhonghua, Koo Bon-Kyung, Patel Anooj, Cascio Duilio, Collins Kathleen, Feigon Juli, Structural basis for telomerase RNA recognition and RNP assembly by the holoenzyme La family protein p65, Molecular cell, 2012, 47 (1), 16-26.
Mahavir Singh, Zhonghua Wang, Bon-Kyung Koo, Anooj Patel, Duilio Cascio, Kathleen Collins, Juli Feigon, Structural Basis for Telomerase RNA Recognition and RNP Assembly by the Holoenzyme La Family Protein p65, Molecular Cell, 2012.
Zhang Qi, Kim Nak-Kyoon, Feigon Juli, Architecture of human telomerase RNA, Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (51), 20325-32.
Koo Bon-Kyung, Park Chin-Ju, Fernandez Cesar F, Chim Nicholas, Ding Yi, Chanfreau Guillaume, Feigon Juli, Structure of H/ACA RNP protein Nhp2p reveals cis/trans isomerization of a conserved proline at the RNA and Nop10 binding interface, Journal of molecular biology, 2011, 411 (5), 927-42.
Wang Zhonghua, Hartman Elon, Roy Kevin, Chanfreau Guillaume, Feigon Juli, Structure of a yeast RNase III dsRBD complex with a noncanonical RNA substrate provides new insights into binding specificity of dsRBDs, Structure (London, England : 1993), 2011, 19 (7), 999-1010.
Zhang Qi, Kang Mijeong, Peterson Robert D, Feigon Juli, Comparison of solution and crystal structures of preQ1 riboswitch reveals calcium-induced changes in conformation and dynamics, Journal of the American Chemical Society, 2011, 133 (14), 5190-3.
Zhang Qi, Kim Nak-Kyoon, Peterson Robert D, Wang Zhonghua, Feigon Juli, Structurally conserved five nucleotide bulge determines the overall topology of the core domain of human telomerase RNA, Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (44), 18761-8.
Kim Nak-Kyoon, Theimer Carla A, Mitchell James R, Collins Kathleen, Feigon Juli, Effect of pseudouridylation on the structure and activity of the catalytically essential P6.1 hairpin in human telomerase RNA, Nucleic acids research, 2010, 38 (19), 6746-56.
Kim NK, Theimer CA, Mitchell JR, Collins K, Feigon J, Effect of pseudouridylation on the structure and activity of the catalytically essential P6.1 hairpin in human telomerase RNA, Nucleic Acids Res, 2010, 38 (19), 6746-56.
Qi Zhanga, Nak-Kyoon Kima, Robert D. Petersona,b, Zhonghua Wanga, and Juli Feigona, Structurally conserved five nucleotide bulge determines the overall topology of the core domain of human telomerase RNA, PNAS, 2010, 107 (44), 18761-8.
Kang Mijeong, Peterson Robert, Feigon Juli, Structural Insights into riboswitch control of the biosynthesis of queuosine, a modified nucleotide found in the anticodon of tRNA, Molecular cell, 2009, 33 (6), 784-90.
Singh Mahavir, Gonzales Fernando A, Cascio Duilio, Heckmann Nathanael, Chanfreau Guillaume, Feigon Juli, Structure and functional studies of the CS domain of the essential H/ACA ribonucleoparticle assembly protein SHQ1, The Journal of biological chemistry, 2009, 284 (3), 1906-16.
Kim Nak-Kyoon, Zhang Qi, Zhou Jing, Theimer Carla A, Peterson Robert D, Feigon Juli, Solution structure and dynamics of the wild-type pseudoknot of human telomerase RNA, Journal of molecular biology, 2008, 384 (5), 1249-61.
Theimer Carla A, Jady B.E., Chim Nicholas, Richard Patricia, Breece Katherine E, Kiss T., Feigon Juli, Structural and functional characterization of human telomerase RNA processing and cajal body localization signals, Mol. Cell, 2007, 27 (6), 869-81.
Januszyk Kurt, Li Patrick Wai-Lun, Villareal Valerie, Branciforte Dan, Wu Haihong, Xie Yongming, Feigon Juli, Loo Joseph A, Martin Sandra L, Clubb Robert T, Identification and solution structure of a highly conserved C-terminal domain within ORF1p required for retrotransposition of long interspersed nuclear element-1, J. Biol. Chem, 2007, 282 (34), 24893-904.
Wu Haihong, Feigon Juli, H/ACA small nucleolar RNA pseudouridylation pockets bind substrate RNA to form three-way junctions that position the target U for modification, Proc. Natl. Acad. Sci. U.S.A, 2007, 104 (16), 6655-60.
Richards Rebecca J, Wu Haihong, Trantirek Lukas, O'Connor Catherine M, Collins Kathleen, Feigon Juli, Structural study of elements of Tetrahymena telomerase RNA stem-loop IV domain important for function, RNA, 2006, 12 (8), 1475-85.
Theimer Carla A, Feigon Juli, Structure and function of telomerase RNA, Curr. Opin. Struct. Biol, 2006, 16 (3), 307-18.
Richards Rebecca J, Theimer Carla A, Finger L David, Feigon Juli, Structure of the Tetrahymena thermophila telomerase RNA helix II template boundary element, Nucleic Acids Res, 2006, 34 (3), 816-25.
Khanna May, Wu Haihong, Johansson Carina, Caizergues-Ferrer Michèle, Feigon Juli, Structural study of the H/ACA snoRNP components Nop10p and the 3' hairpin of U65 snoRNA, RNA, 2006, 12 (1), 40-52.
Dingley Andrew J, Peterson Robert D, Grzesiek Stephan, Feigon Juli, Characterization of the cation and temperature dependence of DNA quadruplex hydrogen bond properties using high-resolution NMR, J. Am. Chem. Soc, 2005, 127 (41), 14466-72.
Henras Anthony K, Sam Mui, Hiley Shawna L, Wu Haihong, Hughes Timothy R, Feigon Juli, Chanfreau Guillaume F, Biochemical and genomic analysis of substrate recognition by the double-stranded RNA binding domain of yeast RNase III, RNA, 2005, 11 (8), 1225-37.
Qin Peter Z, Feigon Juli, Hubbell Wayne L, Site-directed spin labeling studies reveal solution conformational changes in a GAAA tetraloop receptor upon Mg(2+)-dependent docking of a GAAA tetraloop, J. Mol. Biol, 2005, 351 (1), 1-8.
Wu Haihong, Finger L David, Feigon Juli, Structure determination of protein/RNA complexes by NMR, Meth. Enzymol, 2005, 394 (5), 525-45.
Theimer Carla A, Blois Craig A, Feigon Juli, Structure of the human telomerase RNA pseudoknot reveals conserved tertiary interactions essential for function, Mol. Cell, 2005, 17 (5), 671-82.
Kamionka Mariusz, Feigon Juli, Structure of the XPC binding domain of hHR23A reveals hydrophobic patches for protein interaction, Protein Sci, 2004, 13 (9), 2370-7.
Stefl R, Wu H, Ravindranathan S, Sklenar V, Feigon J, DNA A-tract bending in three dimensions: Solving the dA4T4 versus dT4A4 conundrum, Proc. Natl. Acad. Sci. USA, 2004, 101, 1177-1182 .
Peterson R.D., Theimer C.A., Wu H, Feigon J, New Applications of 2D Filtered/Edited NOESY for Assignment and Structure Elucidation of RNA and RNA-Protein Complexes, J. Biomol. NMR, 2004, 28, 59-67.
Feigon J, Bustamante C,, Nucleic acids – controlling biology and controlled by biophysics, Current Opinion in Structural Biology , 2004, 14 (3), 333-334.
Johansson C, Finger L.D., Trantirek L, Mueller T.D., Kim S, I.A. Laird-Offringa, Feigon J, Solution structure of the complex formed by the two N-terminal RNA-binding domains of nucleolin and a pre-rRNA target, J. Mol. Biol, 2004, 337, 799-816.
Mueller T.D., Kamionka M, Feigon J, Specificity of the interaction between UBA domains and ubiquitin, J. Biol. Chem, 2004, 279, 11926-11936.
Wu H, Henras A, Chanfreau G, Feigon J, Structural basis for recognition of the AGNN tetraloop RNA fold by the double-stranded RNA binding domain on Rnt1p Rnase III, Proc. Natl. Acad. Sci, 2004, 101, 8307-8312.
Finger L David, Johansson Carina, Rinaldi Bruno, Bouvet Philippe, Feigon Juli, Contributions of the RNA-binding and linker domains and RNA structure to the specificity and affinity of the nucleolin RBD12/NRE interaction, Biochemistry, 2004, 43 (22), 6937-47.
Wu Haihong, Henras Anthony, Chanfreau Guillaume, Feigon Juli, Structural basis for recognition of the AGNN tetraloop RNA fold by the double-stranded RNA-binding domain of Rnt1p RNase III, Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 (22), 8307-12.
Johansson Carina, Finger L David, Trantirek Lukas, Mueller Thomas D, Kim Soyoun, Laird-Offringa Ite A, Feigon Juli, Solution structure of the complex formed by the two N-terminal RNA-binding domains of nucleolin and a pre-rRNA target, Journal of molecular biology, 2004, 337 (4), 799-816.
Mueller Thomas D, Kamionka Mariusz, Feigon Juli, Specificity of the interaction between ubiquitin-associated domains and ubiquitin, The Journal of biological chemistry, 2004, 279 (12), 11926-36.
Peterson Robert D, Theimer Carla A, Wu Haihong, Feigon Juli, New applications of 2D filtered/edited NOESY for assignment and structure elucidation of RNA and RNA-protein complexes, Journal of biomolecular NMR, 2004, 28 (1), 59-67.
Theimer Carla A, Finger L David, Feigon Juli, YNMG tetraloop formation by a dyskeratosis congenita mutation in human telomerase RNA, RNA (New York, N.Y.), 2003, 9 (12), 1446-55.
Qin P.Z., Hideg K, Feigon J, Hubbell W.L. , Monitoring RNA base structure and dynamics using site-directed spin labeling, Biochemistry, 2003, 42, 6772-6783.
Theimer C.A., Finger L.D., Trantirek L, Feigon J, Mutations linked to dyskeratosis congenita cause dynamic changes in telomerase RNA structure, Proc. Natl. Acad. Sci. USA, 2003, 100, 449-454 .
Finger L.D., Trantirek L, Johansson C, Feigon J, Solution structures of stem-loop RNAs that bind to the two N-terminal RNA-binding domains of nucleolin, Nucleic Acids Res, 2003, 31, 6461-6472 .
Mueller T.M., Feigon J, Structural determinants for the binding of ubiquitin-like domains to the proteasome, EMBO J, 2003, 22, 4634-4645 .
Theimer C.A., Finger L.D., Feigon J., YNMG tetraloop formation by a dyskeratosis congenita mutation in human telomerase RNA, RNA, 2003, 9, 1446-1455 .