California NanoSystems Institute
CNSI
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Timothy Deming, Ph.D.

   
Chair, Bioengineering
Co-Leader, Pilot and Collaborative Translational Clinical Studies Program
Professor, Bioengineering, Chemistry and Biochemistry, Organic Chemistry
Member, California NanoSystems Institute, JCCC Signal Transduction and Therapeutics Program Area
Researcher, Nanoscience and Materials, Organic, Synthesis

Education:
Degrees:
Ph.D., University of California, Berkeley, 1993
B.S., University of California, Irvine, 1989

Academic Experience:
Fellowships:
2002 Institut Curie, Rothschild and Mayent Foundation Fellow
1998 Alfred P. Sloan Research Fellow

Honors and Awards:
Unilever Award for Outstanding Graduate Research in Polymer Chemistry
2004 World Polymer Congress, IUPAC Macromolecular Division, Samsung-IUPAC Young Scientist Award
2003 Materials Research Society, Young Investigator Award
2000 Camille Dreyfus Teacher-Scholar Award
1999 3M, Non-Tenured Faculty Award
1998 Beckman Young Investigator Award
1997 NSF, CAREER Award
1996 UC Regents, Junior Faculty Fellow
1996 Office of Naval Research Young Investigator

Professional Societies:
American Chemical Society

Certifications:
Certification Type:
1993 NIH, National Research Service Award Postdoctoral Fellow

Academic Experience:
Academic Experience:
1993 - 1995 University of Massachusetts, Amherst, MA, Polymer Science

Contact Information:
Work Email Address: demingt@seas.ucla.edu
Office Address: UCLA Bioengineering/Biomedical Engineering
410 Westwood Plaza
BOX 951600, 5121 Engineering V
Los Angeles, CA 90095
Home Page: http://deming.seas.ucla.edu/Welcome.html
Work Phone Number: (310) 207-4450 Office
Lab Number: (310) 204-5956
Technical Research Interest:

Research in the Deming group is focused on synthesis, processing, characterization and evaluation of biological and biomimetic materials based on polypeptides. These materials are being studied since they can be prepared from renewable resources, they can be biocompatible and biodegradable, and possess unique self-assembling properties. We utilize innovative chemistry techniques to synthesize materials with properties that rival the complexity found in biological systems. The polymers are then processed into ordered assemblies, which are characterized for both nanoscale structure as well as biological function. This interdisciplinary approach stimulates innovations and ideas which direct this research into new, exciting areas.


Additional Information:

Timothy J. Deming received a B.S. in Chemistry fom the University of California, Irvine in 1989, and graduated with a Ph.D. in Chemistry from the University of California, Berkeley, under Bruce Novak in 1993. After a NIH postdoctoral fellowship at the University of Massachusetts, Amherst with David Tirrell, he joined the faculty in the Materials Department at the University of California, Santa Barbara in 1995. Here he held a joint appointment in the Materials and Chemistry Departments where he was promoted to Associate Professor in 1999 and Full Professor in 2003. His appointment is now as the Chair of the Bioengineering Department at the University of California, Los Angeles. Current research interests include polypeptide synthesis, self-assembly of block copolypeptides, and biological activity of polypeptides, for which he has received young investigator awards from the National Science Foundation, the Office of Naval Research, The Arnold and Mabel Beckman Foundation, the Alfred P. Sloan Foundation, the Camille and Henry Dreyfus Foundation, the Materials Research Society, and the IUPAC Macromolecular Division.

Selected Publications:

Choe Uh-Joo, Rodriguez April R, Lee Brian S, Knowles Scott M, Wu Anna M, Deming Timothy J, Kamei Daniel T, Endocytosis and intracellular trafficking properties of transferrin-conjugated block copolypeptide vesicles, Biomacromolecules, 2013, 14 (5), 1458-64.
Jiang Ziyue Karen, Koh Sok Boon S, Sato Makoto, Atanasov Ivo C, Johnson Mai, Zhou Z Hong, Deming Timothy J, Wu Lily, Engineering polypeptide coatings to augment gene transduction and in vivo stability of adenoviruses, Journal of controlled release : official journal of the Controlled Release Society, 2013, 166 (1), 75-85.
Kramer Jessica R, Deming Timothy J, Reversible chemoselective tagging and functionalization of methionine containing peptides, Chemical communications (Cambridge, England), 2013, 49 (45), 5144-6.
Kuroiwa Keita, Masaki Yoshitaka, Koga Yuko, Deming Timothy J, Self-Assembly of Discrete Metal Complexes in Aqueous Solution via Block Copolypeptide Amphiphiles, International journal of molecular sciences, 2013, 14 (1), 2022-35.
Sun Victor Z, Choe Uh-Joo, Rodriguez April R, Dai Howard, Deming Timothy J, Kamei Daniel T, Transfection of Mammalian Cells Using Block Copolypeptide Vesicles, Macromolecular bioscience, 2013, 49 (45).
Rodriguez April R, Choe Uh-Joo, Kamei Daniel T, Deming Timothy J, Fine Tuning of Vesicle Assembly and Properties Using Dual Hydrophilic Triblock Copolypeptides, Macromolecular bioscience, 2012.
Kramer Jessica R, Deming Timothy J, Glycopolypeptides with a redox-triggered helix-to-coil transition, Journal of the American Chemical Society, 2012, 134 (9), 4112-5.
Kramer Jessica R, Deming Timothy J, Preparation of Multifunctional and Multireactive Polypeptides via Methionine Alkylation, Biomacromolecules, 2012.
Song Bingbing, Song Jinsuk, Zhang Shanshan, Anderson Mark A, Ao Yan, Yang Chu-Ya, Deming Timothy J, Sofroniew Michael V, Sustained local delivery of bioactive nerve growth factor in the central nervous system via tunable diblock copolypeptide hydrogel depots, Biomaterials, 2012, 33 (35), 9105-16.
Cheng Jianjun, Deming Timothy J, Synthesis of polypeptides by ring-opening polymerization of α-amino acid N-carboxyanhydrides, Topics in current chemistry, 2012, 310, 1-26.
Rhodes Allison J, Deming Timothy J, Tandem catalysis for the preparation of cylindrical polypeptide brushes, Journal of the American Chemical Society, 2012, 134 (47), 19463-7.
Sun Victor Z, Li Zhibo, Deming Timothy J, Kamei Daniel T, Intracellular fates of cell-penetrating block copolypeptide vesicles, Biomacromolecules, 2011, 12 (1), 10-3.
Mishra Abhijit, Lai Ghee Hwee, Schmidt Nathan W, Sun Victor Z, Rodriguez April R, Tong Rong, Tang Li, Cheng Jianjun, Deming Timothy J, Kamei Daniel T, Wong Gerard C L, Translocation of HIV TAT peptide and analogues induced by multiplexed membrane and cytoskeletal interactions, Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (41), 16883-8.
Kramer Jessica R, Deming Timothy J, General method for purification of α-amino acid-n-carboxyanhydrides using flash chromatography, Biomacromolecules, 2010, 11 (12), 3668-72.
Kramer Jessica R, Deming Timothy J, Glycopolypeptides via living polymerization of glycosylated-L-lysine N-carboxyanhydrides, Journal of the American Chemical Society, 2010, 132 (42), 15068-71.
Hanson Jarrod A, Li Zhibo, Deming Timothy J, Nonionic Block Copolypeptide Micelles Containing a Hydrophobic racemic-Leucine Core, Macromolecules, 2010, 43 (15), 6268-6269.
Deming Timothy J, Regenerative medicine: Noodle gels for cells, Nature materials, 2010, 9 (7), 535-6.
Holowka Eric P, Deming Timothy J, Synthesis and crosslinking of L-DOPA containing polypeptide vesicles, Macromolecular bioscience, 2010, 10 (5), 496-502.
Li ZB, Deming TJ, Tunable hydrogel morphology via self-assembly of amphiphilic pentablock copolypeptides, SOFT MATTER , 2010, 6 (11), 2546-2551.
Yang Chu-Ya, Song Bingbing, Ao Yan, Nowak Andrew P, Abelowitz Ryan B, Korsak Rose A, Havton Leif A, Deming Timothy J, Sofroniew Michael V, Biocompatibility of amphiphilic diblock copolypeptide hydrogels in the central nervous system, Biomaterials, 2009, 30 (15), 2881-98.
Yan-Yan Hu, Yusuf Yusufoglu, Mathumai Kanapathipillai, Chu-Ya Yang, YaQiao Wu, Papannan Thiyagarajan, Timothy Deming, Mufit Akinc, Klaus Schmidt-Rohr and Surya Mallapragada, Self-assembled calcium phosphate nanocomposites using block copolypeptide templates, SOFT MATTER, 2009, 5 (21), 4311-4320.
Hanson Jarrod A, Chang Connie B, Graves Sara M, Li Zhibo, Mason Thomas G, Deming Timothy J, Nanoscale double emulsions stabilized by single-component block copolypeptides, Nature, 2008, 455 (7209), 85-8.
Auguste Debra T, Furman Kay, Wong Andrew, Fuller Jason, Armes Steven P, Deming Timothy J, Langer Robert, Triggered release of siRNA from poly(ethylene glycol)-protected, pH-dependent liposomes, Journal of controlled release : official journal of the Controlled Release Society, 2008, 130 (3), 266-74.
Klok, H.A., Deming, T.J.; Gnanou, Y., Matyjaszewski, K., Leibler, L. , Macromolecular Engineering of Polypeptides using the Ring Opening Polymerization of Alpha-Amino Acid N Carboxy Anhydrides, Macromolecular Engineering, 2007, 1, 519-540.
Holowka Eric P, Sun Victor Z, Kamei Daniel T, Deming Timothy J, Polyarginine segments in block copolypeptides drive both vesicular assembly and intracellular delivery, Nature materials, 2007, 6 (1), 52-7.
Nowak, A.P., Sato. J., Breedveld, V., Deming, T.J., Hydrogel Formation in Amphiphilic Triblock Copolypeptides, Supramolecular Chemistry, 2006 (18), 429-427.
Bellomo Enrico G, Deming Timothy J, Monoliths of aligned silica-polypeptide hexagonal platelets, Journal of the American Chemical Society, 2006, 128 (7), 2276-9.
Deming, T.J., Polypeptide abd Polypeptide Hybrid Copolymer Synthesis via NCA Polymerization, Adv. Polym. Sci, 2006 (202), 1-8.
Schaefer, K.E., Keller, P., Deming, T.J., Thermotropic Polypeptides Bearing Side-On Mesogens, Macromolecules, 2006 (39), 19-22.
Auguste Debra T, Armes Steven P, Brzezinska Krystyna R, Deming Timothy J, Kohn Joachim, Prud'homme Robert K, pH triggered release of protective poly(ethylene glycol)-b-polycation copolymers from liposomes, Biomaterials, 2006, 27 (12), 2599-608.
Cui, H.; Krikorian, V.; Thompson, J.; Nowak, A. P.; Deming, T. J.; Pochan, D. J., "Preparation and Characterization of Synthetic Polypeptide Single Crystals with Controlled Thickness", Macromolecules , 2005, 38, 7371-7377.
Holowka Eric P, Pochan Darrin J, Deming Timothy J, Charged polypeptide vesicles with controllable diameter, Journal of the American Chemical Society, 2005, 127 (35), 12423-8.
Deming, T. J. , Polypeptide Hydrogels via a Unique Assembly Mechanism, Soft Matter, 2005 (1), 28-35.
Tomczak Melanie M, Glawe Diana D, Drummy Lawrence F, Lawrence Charles G, Stone Morley O, Perry Carole C, Pochan Darrin J, Deming Timothy J, Naik Rajesh R, Polypeptide-templated synthesis of hexagonal silica platelets, Journal of the American Chemical Society, 2005, 127 (36), 12577-82.
Bellomo Enrico G, Davidson Patrick, Impéror-Clerc Marianne, Deming Timothy J, Aqueous cholesteric liquid crystals using uncharged rodlike polypeptides, Journal of the American Chemical Society, 2004, 126 (29), 9101-5.
Euliss Larken E, Trnka Tina M, Deming Timothy J, Stucky Galen D, Design of a doubly-hydrophilic block copolypeptide that directs the formation of calcium carbonate microspheres, Chemical communications (Cambridge, England), 2004, 43 (15), 1736-7.
Pakstis Lisa M, Ozbas Bulent, Hales Kelly D, Nowak Andrew P, Deming Timothy J, Pochan Darrin, Effect of chemistry and morphology on the biofunctionality of self-assembling diblock copolypeptide hydrogels, Biomacromolecules, 2004, 5 (2), 312-8.
McKenna Brandon J, Birkedal Henrik, Bartl Michael H, Deming Timothy J, Stucky Galen D, Micrometer-sized spherical assemblies of polypeptides and small molecules by acid-base chemistry, Angewandte Chemie (International ed. in English), 2004, 43 (42), 5652-5.
Breedveld, V.; Nowak, A. P.; Sato, J.; Deming, T. J.; Pine, D. J., Rheology of Block Copolypeptide Solutions: Hydrogels with Tunable Properties, Macromolecules, 2004, 37, 3943-3953.
Minich, E. A.; Nowak, A. P.; Deming, T. J.; Pochan, D. J., Rod–rod and rod–coil self-assembly and phase behavior of polypeptide diblock copolymers, Polymer, 2004, 45 (6), 1951-1957.
Bellomo Enrico G, Wyrsta Michael D, Pakstis Lisa, Pochan Darrin J, Deming Timothy J, Stimuli-responsive polypeptide vesicles by conformation-specific assembly, Nature materials, 2004, 3 (4), 244-8.
Brzezinska Krystyna R, Deming Timothy J, Synthesis of AB diblock copolymers by atom-transfer radical polymerization (ATRP) and living polymerization of alpha-amino acid-N-carboxyanhydrides, Macromolecular bioscience, 2004, 4 (6), 566-9.
Cha, J. N.; Bartl, M. H.; Wong, M. S.; Popitsch, A.; Deming, T. J.; Stucky, G. D., Microcavity Lasing from Block Peptide Hierarchically Assembled Quantum Dot Spherical Resonators, Nano Lett, 2003, 3, 907-911.
Cha Jennifer N, Birkedal Henrik, Euliss Larken E, Bartl Michael H, Wong Michael S, Deming Timothy J, Stucky Galen D, Spontaneous formation of nanoparticle vesicles from homopolymer polyelectrolytes, Journal of the American Chemical Society, 2003, 125 (27), 8285-9.
Nowak Andrew P, Breedveld Victor, Pine David J, Deming Timothy J, Unusual salt stability in highly charged diblock co-polypeptide hydrogels, Journal of the American Chemical Society, 2003, 125 (50), 15666-70.
Seidel, S. W.; Deming, T. J., Use of Chiral Ruthenium and Iridium Amido-Sulfonamidate Complexes for Controlled, Enantioselective Polypeptide Synthesis, Macromolecules , 2003, 36 (4), 969-972.
Wong, M. S.; Cha, J. N.; Choi, K-S.; Deming, T. J.; Stucky, G. D., Assembly of Nanoparticles into Hollow Spheres Using Block Copolypeptides”, Nano Letters, 2002, 2 (6), 583-587.
Deming Timothy J, Methodologies for preparation of synthetic block copolypeptides: materials with future promise in drug delivery, Advanced drug delivery reviews, 2002, 54 (8), 1145-55.
Brzezinska, K. R.; Curtin, S. A.; Deming, T. J., Polypeptide End-capping Using Functionalized Isocyanates: Preparation of Pentablock Copolymers, Macromolecules, 2002, 35 (8), 2970-2976.
Krikorian, V.; Kurian, M.; Galvin, M. E.; Nowak, A. P.; Deming, T. J.; Pochan, D. J., Polypeptide-based Nanocomposite: Structure and Properties of Poly(L-lysine)/Na+-montmorillonite, Polymer Sci. Polym. Phys, 2002, 40, 2579-2586.
Nowak Andrew P, Breedveld Victor, Pakstis Lisa, Ozbas Bulent, Pine David J, Pochan Darrin, Deming Timothy J, Rapidly recovering hydrogel scaffolds from self-assembling diblock copolypeptide amphiphiles, Nature, 2002, 417 (6887), 424-8.
Pochan, D. J.; Pakstis, L.; Ozbas, B.; Nowak, A. P.; Deming, T. J., SANS and Cryo-TEM Study of Self-Assembled Diblock Copolypeptide Hydrogels with Rich Nano- through Microscale Morphology, Macromolecules, 2002, 35 (14), 5358-5360.