California NanoSystems Institute
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Dolores Bozovic, Ph.D.

Associate Professor, Physics and Astronomy
Member, California NanoSystems Institute

Ph.D., Harvard University, Cambridge, MA, 2001

Contact Information:
Email Address:
Mailing Address: Mail Code: 154705
Los Angeles, CA 90095
Office Phone Number: (310) 825-6176
Technical Research Interest:

Hair cells of the inner ear perform the first step in the detection and analysis of incoming sound. These small biological mechanoelectrical transducers display remarkable sensitivity, as they are able to detect deflections smaller than a nanometer. At the same time, they can withstand very loud sounds, covering a total range of 6 orders of magnitude in the applied pressure. Their proper functioning has been shown to require the presence of an active process, one which consumes energy to provide amplification of the incoming stimulus, and whose gain is tuned in response to the environment. The mechanisms behind this active process, however, remain unknown. In this laboratory, we plan to further study the role of the nano-scale transduction apparatus in the overall mechanical responsiveness of a hair cell. Most of the single-cell measurements done to date have been performed on cells that specialize in the detection of low-frequency signals. We look forward to collaborating with other members of the CNSI to develop the technology that would push these measurements to the higher-frequency regimes relevant to our own hearing.

Selected Publications:

Strimbu CE, Kao A, Tokuda J, Ramunno-Johnson D, Bozovic D, Dynamic state and evoked motility in coupled hair bundles of the bullfrog sacculus, Hearing Research, 2010, 65 (1-2), 38-45.
Ramunno-Johnson D, Strimbu CE, Kao A, Hemsing LF, Bozovic D, Effects of the somatic ion channels upon spontaneous mechanical oscillations in hair bundles of the inner ear, Hearing Research, 2010, 8 (1-2), 163-171.
Strimbu C.E., Ramunno-Johnson D., Frederickson L., Arisaka K., Bozovic D. , Correlated Movement of Hair Bundles Coupled to the Otolithic Membrane in the Bullfrog Sacculus, Hear. Res, 2009, 256 (1-2), 58-63.
Ramunno-Johnson, D. Strimbu, C. E. Fredrickson, L. Arisaka, K. Bozovic, D., Distribution of Frequencies of Spontaneous Oscillations in Hair Cells of the Bullfrog Sacculus, Biophysical Journal , 2009, 96 (3), 1159-1168.
Frederickson L., Cheng A., Strimbu C.E., Bozovic D., Arisaka K., The Use of a CMOS camera to resolve nanometer displacements of hair cell stereocilia in the bullfrog sacculus, Proc. of the SPIE, 2008, 6859 (6859B).
Le Goff, L Bozovic, D Hudspeth, AJ, Adaptive shift in the domain of negative stiffness during spontaneous oscillation by hair bundles from the internal ear, Proceedings of the National Academy of Sciences of the United States of America, 2005, 102 (47), 16996-7001.
Le Goff, L. Bozovic, D. Hudspeth, A. J., Dissecting the mechanical states of an oscillating hair bundle, Biophysical Journal, 2005, 88 (1), 287A-287A .
Bozovic, D Hudspeth, AJ, Hair-bundle movements elicited by transepithelial electrical stimulation of hair cells in the sacculus of the bullfrog, Proceedings of the National Academy of Sciences of the United States of America. , 2003, 100 (3), 958-63.
Bozovic, D., Bockrath, M., Hafner, J. H., Lieber, C. M., Park, H. & Tinkham, M., Plastic deformations in mechanically strained single-walled carbon nanotubes, Phys. Rev. B , 2003, 67 (3), 34407-34410.
Martin, P Bozovic, D Choe, Y Hudspeth, AJ, Spontaneous oscillation by hair bundles of the bullfrog's sacculus, The Journal of Neuroscience, 2003, 23 (11), 4533-48.